Results 91 to 100 of about 1,665,599 (197)

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia

, 2021
There is evidence that ATM mutated in ataxia-telangiectasia (A-T) plays a key role in protecting against mitochondrial dysfunction, the mechanism for which remains unresolved.
Lavin, MF, Yeo, AJ, Chong, KL, Wolvetang, E, Zou, D, Kastan, MB, Gatei, M, Withey, S, Brown, AD, Parton, RG, Stewart, R, Coman, D   +11 more
core   +1 more source

The PSO4 Protein Complex Associates with Replication Protein A (RPA) and Modulates the Activation of Ataxia Telangiectasia-mutated and Rad3-related (ATR) [PDF]

Journal of Biological Chemistry, 2014
The PSO4 core complex is composed of PSO4/PRP19/SNEV, CDC5L, PLRG1, and BCAS2/SPF27. Besides its well defined functions in pre-mRNA splicing, the PSO4 complex has been shown recently to participate in the DNA damage response. However, the specific role for the PSO4 complex in the DNA damage response pathways is still not clear.
Li, Wan, Jun, Huang
openaire   +2 more sources

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

Procyanidin A1 and its digestive products inhibit acrylamide-induced IPEC-J2 cell damage: apoptosis and cell cycle arrest

Food Science and Human Wellness
Our previous study has demonstrated that procyanidin A1 (A1) and its simulated digestive product (D-A1) can prevent acrylamide (ACR)-induced cytotoxicity in small intestine cells. However, the potential mechanism remains poorly understood. In this study,
Fangfang Yan, Si Qin, Chengming Wang, Wolfram Weckwerth, Qun Lu, Rui Liu   +5 more
doaj   +1 more source

Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions [PDF]

Proceedings of the National Academy of Sciences, 2011
Antigen receptor variable region exons are assembled during lymphocyte development from variable (V), diversity (D), and joining (J) gene segments. Each germ-line gene segment is flanked by recombination signal sequences (RSs). Recombination-activating gene endonuclease initiates V(D)J recombination by cleaving a pair of gene segments at their junction
Shan, Zha, Wenxia, Jiang, Yuko, Fujiwara, Harin, Patel, Peter H, Goff, James W, Brush, Richard L, Dubois, Frederick W, Alt   +7 more
openaire   +2 more sources

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Integrated multi‐omics analysis of post‐translational modifications in head and neck squamous cell carcinoma: elucidating x‐ray and carbon ion irradiation effects

Precision Radiation Oncology, EarlyView.
This study underscores the critical role of PTMs in mediating cellular responses to X‐ray and Carbon ion irradiation radiotherapy in HNSCC. The integration of multi‐omics data provides insights into the molecular mechanisms underlying radiation‐induced changes, offering valuable clues for improving therapeutic outcomes and advancing precision medicine ...
Fan‐Tong Xia, Zhi‐Yun Liao, Si‐Qi Cai, Li‐Rong Zhou, Meng‐Qi Yang, Xin Zhang, Dan Li, Huan Zhang, Yun‐Chang Liu, Jie‐Ying Yang, Jia Jiang, Yi‐Hong Hu, Jiang‐Dong Sui, Ying Wang   +13 more
wiley   +1 more source

ATAXIA-TELANGIECTASIA - A CASE REPORT [PDF]

, 2005
RESUMO A ataxia-telengiectasia (AT) é uma doença genética, autossómica recessiva, causada pela mutação do gene ATM, localizado no cromosoma 11q22-23.
Veiga, E., Gaspar, M., Fonseca, M., Caturra, L.   +3 more
core  

Conjunctival Telangiectasia in a Patient with Ataxia Telangiectasia: A Case Report

, 2012
The purpose of this paper is to report a 7-year-old patient who developed bilateral conjunctival hyperemia while being under treatment of pneumonia in Pediatric Infectious Diseases Clinic at Sisli Etfal Training and Research Hospital.
Dilek Güven, Özge Pınar Akarsu, Cemile Üçgül Atılgan   +2 more
core   +1 more source