Results 101 to 110 of about 41,016 (281)

Activation of Ataxia Telangiectasia-mutated DNA Damage Checkpoint Signal Transduction Elicited by Herpes Simplex Virus Infection*

Journal of Biological Chemistry, 2005
Eukaryotic cells are equipped with machinery to monitor and repair damaged DNA. Herpes simplex virus (HSV) DNA replication occurs at discrete sites in nuclei, the replication compartment, where viral replication proteins cluster and synthesize a large ...
Noriko Shirata, A. Kudoh, T. Daikoku, Yasutoshi Tatsumi, M. Fujita, T. Kiyono, Y. Sugaya, Hiroki Isomura, K. Ishizaki, T. Tsurumi   +9 more
semanticscholar   +1 more source

Mice Lacking Protein Phosphatase 5 Are Defective in Ataxia Telangiectasia Mutated (ATM)-mediated Cell Cycle Arrest [PDF]

Journal of Biological Chemistry, 2007
Protein phosphatase 5 (Ppp5), a tetratricopeptide repeat domain protein, has been implicated in multiple cellular functions, including cellular proliferation, migration, differentiation and survival, and cell cycle checkpoint regulation via the ataxia telangiectasia mutated/ATM and Rad3-related (ATM/ATR) signal pathway.
Weidong, Yong, Shideng, Bao, Hanying, Chen, Dapei, Li, Edwin R, Sánchez, Weinian, Shou   +5 more
openaire   +2 more sources

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells

Applied Microbiology and Biotechnology
Several strategies have been developed in recent years to improve virus-like particle (VLP)-based vaccine production processes. Among these, the metabolic engineering of cell lines has been one of the most promising approaches. Based on previous work and
Andy Díaz-Maneh, Pol Pérez-Rubio, Cristina Rigau Granes, Laia Bosch-Molist, Jesús Lavado-García, Francesc Gòdia, Laura Cervera   +6 more
doaj   +1 more source

Mutation analysis of multiple pilomatricomas in a patient with myotonic dystrophy type 1 suggests a DM1-associated hypermutation phenotype.

PLoS ONE, 2020
Myotonic dystrophy type 1 (DM1) is an inherited neuromuscular disease which results from an expansion of repetitive DNA elements within the 3' untranslated region of the DMPK gene. Some patients develop multiple pilomatricomas as well as malignant tumors
Albert Rübben, Renate Ursula Wahl, Thomas Eggermann, Edgar Dahl, Nadina Ortiz-Brüchle, Claudio Cacchi   +5 more
doaj   +1 more source

Chk2 is a tumour suppressor that regulates apoptosis in both an ataxia telangiectasia mutad (ATM)-dependent and an ATM-independent manner [PDF]

, 2002
In response to ionizing radiation (IR), the tumor suppressor p53 is stabilized and promotes either cell cycle arrest or apoptosis. Chk2 activated by IR contributes to this stabilization, possibly by direct phosphorylation.
Hirao, Atsushi, Cheung, Alison, Duncan, Gordon, Girard, Pierre-Marie, Elia, Andrew J, Wakeham, Andrew, Okada, Hitoshi, Sarkissian, Talin, Wong, Jorge A, Sakai, Takashi, de Stanchina, Elisa, Bristow, Robert G, Suda, Toshio, Lowe, Scott W, Jeggo, Penny A, Elledge, Stephen J, Mak, Tak W   +16 more
core   +2 more sources

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Effect of Ultraviolet B Irradiation on Melanin Content Accompanied by the Activation of p62/GATA4-Mediated Premature Senescence in HaCaT Cells

Dose-Response, 2022
Objective To explore the effect and mechanism of ultraviolet B (UVB) on melanin synthesis and premature senescence in human immortalized keratinocytes (HaCaT) cells. Methods HaCaT cells were irradiated with 0, 20, 50, 80, 100, 150, and 200 mJ/cm 2 of UVB.
Juan Yan, Li-Ping Ma, Fang Liu, Bo Sun, Mei Tian, Xue Lu, Hai-Xiang Liu, Ling Gao, Qing-Jie Liu   +8 more
doaj   +1 more source

Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us [PDF]

, 2009
The DNA damage response (DDR) mechanisms represent a vital line of defense against exogenous and endogenous DNA damage to enhance two distinct outcomes, survival and the maintenance of genomic stability. The latter is critical for cancer avoidance.
Jeggo, Peggy A.
core   +2 more sources

Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellular DSB repair

Virology Journal, 2008
Retroviral transduction involves integrase-dependent linkage of viral and host DNA that leaves an intermediate that requires post-integration repair (PIR).
Wu Kou-Juey, Zhang Hui, Wang Feng-Xiang, Smith Johanna A, Williams Kevin, Daniel René   +5 more
doaj   +1 more source