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The Role of HPV and Hormone in Cervical Precancer and Cancer: Molecular Pathophysiology and Cell Biology of Disease and Treatment. [PDF]
Oncol ResKao PY, Chen JH, Chen KH.
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Translational Aspects of DNA Damage Repair in Optimizing Cancer Chemotherapy. [PDF]
Adv Genet (Hoboken)Lin A +7 more
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Variant Ataxia-Telangiectasia Presenting as Tremor-Dystonia Syndrome in a Bulgarian Religious Minority. [PDF]
Genes (Basel)Chamova T +13 more
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Targeting the Ataxia Telangiectasia Mutated Protein in Cancer Therapy
Current Drug Targets, 2016Genotoxic anticancer drugs explicate their effects damaging DNA, thus triggering a coordinated signal-transduction network called DNA Damage Response (DDR). Ataxia Telangiectasia Mutated (ATM) protein plays a central role in this response: activated by DNA damage, ATM phosphorylates itself and downstream effectors that arrest cell cycle allowing for ...
Donatella, Vecchio, Guido, Frosina
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Anticancer research, 2015
The expression patterns of the key DNA damage response-related proteins, ataxia-telangiectasia and tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3 (RAD3)-related (ATR) and ataxia-telangiectasia-mutated (ATM) proteins in ovarian cancer are not well-known.
Banghyun, Lee +7 more
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The expression patterns of the key DNA damage response-related proteins, ataxia-telangiectasia and tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3 (RAD3)-related (ATR) and ataxia-telangiectasia-mutated (ATM) proteins in ovarian cancer are not well-known.
Banghyun, Lee +7 more
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International Journal of Radiation Biology, 1999
To provide an update on the product of the ATM gene mutated in the human genetic disorder ataxia-telangiectasia (A-T).The product of the ATM gene mutated in the human genetic disorder A-T is a 350 kDa protein that plays a central role in the regulation of a number of cellular processes.
Lavin, Martin F., Khanna, Kum Kum
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To provide an update on the product of the ATM gene mutated in the human genetic disorder ataxia-telangiectasia (A-T).The product of the ATM gene mutated in the human genetic disorder A-T is a 350 kDa protein that plays a central role in the regulation of a number of cellular processes.
Lavin, Martin F., Khanna, Kum Kum
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Journal of Medical Imaging and Radiation Oncology, 2009
SummaryMalignant myoepithelioma of the breast (MMB) is a rare and often aggressive disease with poor prognosis. Little is known regarding its optimal treatment and progression. We describe the clinical history of a woman following excision of a benign adenomyoepithelioma which recurred years later as a radioresistant malignant myoepithelioma with high ...
Fang Z. M. +8 more
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SummaryMalignant myoepithelioma of the breast (MMB) is a rare and often aggressive disease with poor prognosis. Little is known regarding its optimal treatment and progression. We describe the clinical history of a woman following excision of a benign adenomyoepithelioma which recurred years later as a radioresistant malignant myoepithelioma with high ...
Fang Z. M. +8 more
openaire +5 more sources
Analytical Chemistry, 2011
We have developed a nanotube-based colorimetric probe using multiwalled carbon nanotubes (MWNTs), anti-immunoglobulin G (anti-IgG), and horseradish peroxidase (HRP). The probe was used as an alternative to conventional colorimetric conjugates to obtain amplified signals in a sandwich-type immunoassay for ataxia telangiectasia mutated (ATM), a potential
Qingzhi, Zhang +5 more
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We have developed a nanotube-based colorimetric probe using multiwalled carbon nanotubes (MWNTs), anti-immunoglobulin G (anti-IgG), and horseradish peroxidase (HRP). The probe was used as an alternative to conventional colorimetric conjugates to obtain amplified signals in a sandwich-type immunoassay for ataxia telangiectasia mutated (ATM), a potential
Qingzhi, Zhang +5 more
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Molecular Genetics and Metabolism, 2000
Previous studies on a limited number of ataxia-telangiectasia (A-T) patients with detectable levels of intracellular ATM protein have suggested a genotype/phenotype correlation. We sought to elucidate this possible correlation by comparing ATM protein levels with mutation types, radiosensitivity, and clinical phenotype.
S G, Becker-Catania +9 more
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Previous studies on a limited number of ataxia-telangiectasia (A-T) patients with detectable levels of intracellular ATM protein have suggested a genotype/phenotype correlation. We sought to elucidate this possible correlation by comparing ATM protein levels with mutation types, radiosensitivity, and clinical phenotype.
S G, Becker-Catania +9 more
openaire +2 more sources