Results 51 to 60 of about 146,006 (289)

A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence

Advanced Science, EarlyView.
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Xiaoxia Chang, Jiaxin Yu, Hangkun Yu, Chunxia Gong, Jie Xiong, Philip N. Baker, Yong Fu, Chao Tong   +11 more
wiley   +1 more source

Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions

Advanced Science, EarlyView.
This study uncovers a tri‐directional interplay among cells, hydrogels, and their nascent extracellular matrix. Hydrogel norbornene modification alters CD44‐mediated cell–hydrogel interactions, which shape nascent matrix deposition, composition, and spatial organization.
Joshua Y. Liu, Ziqian Yang, Arina E. Velieva, Eleanor M. Plaster, Mingyue Fan, Donia W. Ahmed, Avinava Roy, Pamela Duran, Pamela Panovich, Alexandra S. Piotrowski‐Daspit, Carlos A. Aguilar, Megan L. Killian, Claudia Loebel   +12 more
wiley   +1 more source

Iron lattice before ATC, 2013

, 2013
January 2013 - Iron lattice overlay before ATC. Part of a 2014 exhibition of photographic works featuring the construction of Swinburne's Advanced Technologies Centre (ATC) and Advanced Manufacturing and Design Centre (AMDC), by Peter ...
Peter Garnick
core   +1 more source

Cattle-Urine-Enriched Biochar Enhances Soil Fertility, Nutrient Uptake, and Yield of Maize in a Low-Productive Soil

Nitrogen
Poor soil fertility, imbalanced fertilization, and limited use of organic fertilizer by farmers are significant limitations contributing to lower crop productivity in Nepal.
Naba Raj Pandit, Pragati Sipkhan, Shiva Shankar Sharma, Darmaraj Dawadi, Shree Prasad Vista, Prashant Raut   +5 more
doaj   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Acute toxicological and behavioural effects of perfluorohexanoic acid (PFHxA) in the model nematode, Caenorhabditis elegans

Environmental Challenges
Perfluorohexanoic acid (PFHxA) has emerged as a significant environmental contaminant driven by the industrial transition to short-chain perfluoroalkyl substances.
Tanmoy Sana, Manjurul Islam Chowdhury, Panneerselvan Logeshwaran, Mallavarapu Megharaj   +3 more
doaj   +1 more source

Coamorphous Atorvastatin Calcium to Improve its Physicochemical and Pharmacokinetic Properties

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Purpose: Atorvastatin calcium (ATC) is classified as class II (low solubility and high permeability) compound according to the biopharmaceutical classification system.
Ali Shayanfar, Hamed Ghavimi, Hamed Hamishekar, Abolghasem Jouyban   +3 more
doaj   +1 more source

ATC-Anno

, 2020
ATC-Anno is an annotation tool for the transcription and semantic annotation of air traffic control utterances. If you use the tool in your research, please cite the associated paper: Marc Schulder, Johannah O'Mahony, Yury Bakanouski, Dietrich Klakow ...
Marc Schulder (7875218), Yury Bakanouski, Marc Schulder, Yury Bakanouski (8540055)   +3 more
core   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Sistemas de Señalización para el Control Automático de Sistemas ferroviarios

Prisma Tecnológico, 2016
El presente artículo de divulgación tecnológica/científica tiene como propósito presentar, brevemente, las definiciones, características y esquemas más sobresalientes de la señalización ferroviaria.
Aranzazu Berbey, Rony Caballero, Humberto Alvarez, José Laguardia, Delva Batista, Darío Solís, Juan de Dios Sanz, Ramón Galán, Juan Andrés Brunel   +8 more
doaj