Acute and chronic toxicity of potassium bromate (KBrO₃) in zebrafish (Danio rerio): Behavioural and hepatic effects [PDF]
Toxicology ReportsPotassium bromate (KBrO₃) is a known food additive and environmental pollutant with documented oxidative and genotoxic effects in mammals, yet its impact on aquatic organisms remains poorly characterized.
Sandeep R. Reddy +2 more
doaj +2 more sources
Cross-Species Triage of SERT-Oriented Polyheteroaryl Candidates Prioritizes AD20/UtIA-0108 as an Early Neuroactive Candidate [PDF]
Current Issues in Molecular BiologyDepression and stress-related disorders remain important targets for the development of new neuroactive compounds. We evaluated three imidazo[1,2-a]pyridine–[1,2,5]oxadiazolo[3,4-b]pyrazine derivatives, selected by a SERT-oriented computational screen ...
Maria V. Komelkova +16 more
doaj +2 more sources
Toxicity of λ-cyhalothrin and fenpyroximate on Nannotrigona testaceicornis - datasetZENODO [PDF]
Data in BriefThe use of pesticides in agriculture boosts food production yields. However, pesticides are directly linked to declining pollinator populations, consequently impacting crop productivity.
Nuno G.C. Ferreira +6 more
doaj +2 more sources
Intracerebroventricular diphtheria toxin causes off-target toxicity in CD11b-DTR and wild-type mice, revealing limitations of DTR-based depletion studies [PDF]
Frontiers in NeuroscienceDiphtheria toxin receptor (DTR)–based depletion models are widely used to study microglial and macrophage function, yet the extent to which diphtheria toxin (DT) produces off-target effects remains incompletely defined.
Jessica Irving +7 more
doaj +2 more sources
Journal of Basic and Applied Zoology, 2015 The present study was undertaken to evaluate the median lethal concentration (LC50), morphological deformities and changes in behavioural responses caused by commercial formulations of malathion on Duttaphrynus melanostictus tadpoles.
M. David, R.M. Kartheek
doaj +3 more sources
Drosophila as a model in organophosphate toxicology [PDF]
FlyOrganophosphates (OPs) cause acute cholinergic toxicity, oxidative stress, DNA damage, and delayed axonopathy through neuropathy target esterase (NTE) inhibition. Efficient in vivo models capturing this toxicity spectrum are essential for risk assessment
Marta Tkachuk, Nataliya Matiytsiv
doaj +2 more sources
Comprehensive dose-dependent hepatorenal protective effects of Ziziphus nummularia leaf extract against quinolphos-induced toxicity in Wistar rats [PDF]
Frontiers in PharmacologyQuinolphos pose considerable hepatorenal toxicity risks, potentially necessitating the investigation of natural protective agents. This study assessed the pharmacological effects of Z.
Ramya Rengaraj +9 more
doaj +2 more sources
Quantifying feature importance for online content moderation [PDF]
EPJ Data ScienceAccurately estimating how users respond to moderation interventions is key to designing effective and user-centred moderation strategies. This requires understanding which user characteristics are associated with different behavioural responses.
Benedetta Tessa +4 more
doaj +2 more sources
Environmental Challenges, 2023 Perfluorobutanoic acid (PFBA) is ubiquitous in the environment, and its concentrations are likely to increase with time due to its usage as a substitute for the restricted long-chain per- and polyfluoroalkyl substances (PFAS). Consequently, concerns have
Tanmoy Sana +3 more
doaj +1 more source
Environmental Advances, 2021 Perfluorooctanoic acid (PFOA) is a prevalent, persistent organic pollutant (POP) in the environment. The potential toxic impacts of PFOA on human and ecological health is becoming an increasing concern worldwide.
Tanmoy Sana +4 more
doaj +1 more source