Results 41 to 50 of about 1,029,768 (285)

Acute toxicological and behavioural effects of perfluorohexanoic acid (PFHxA) in the model nematode, Caenorhabditis elegans

Environmental Challenges
Perfluorohexanoic acid (PFHxA) has emerged as a significant environmental contaminant driven by the industrial transition to short-chain perfluoroalkyl substances.
Tanmoy Sana, Manjurul Islam Chowdhury, Panneerselvan Logeshwaran, Mallavarapu Megharaj   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Challenges for the development of a biotic ligand model predicting copper toxicity in estuaries and seas [PDF]

, 2012
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 SETAC.An effort is ongoing to develop a biotic ligand model (BLM) that predicts copper (Cu) toxicity in estuarine and marine ...
Anna de Polo, Scrimshaw, MD, Mark D. Scrimshaw, de Polo, A   +3 more
core   +1 more source

Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles

IET Nanobiotechnology, 2021
Silicon dioxide nanoparticles (SiO2 NPs) are widely invested in medicine, industry, agriculture, consuming products, optical imaging agents, cosmetics, and drug delivery.
Bashir Jarrar, Amin Al‐Doaiss, Ali Shati, Mohammed Al‐Kahtani, Qais Jarrar   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Comparative toxicity assessment of nanosilver on three Daphnia species in acute, chronic and multi-generation experiments [PDF]

, 2013
The antibacterial properties of nanosilver have led to a versatile application spectrum including medical purposes and personal care products. However, the increasing use of nanosilver has raised concerns about its environmental impacts.
Völker, Carolin, Cathinka Boedicker, Matthias Oetken (74114), Boedicker, Cathinka, Oehlmann, Jörg, Oetken, Matthias, Matthias Oetken, Cathinka Boedicker (467537), Daubenthaler, Jan, Jan Daubenthaler (467538), Jörg Oehlmann, Carolin Völker (467536), Jan Daubenthaler, Jörg Oehlmann (74061), Carolin Völker   +14 more
core   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo

Scientific Reports, 2023
Plastic pollution, especially by nanoplastics (NPs), has become an emerging topic due to the widespread existence and accumulation in the environment.
Narmin Bashirova, David Poppitz, Nils Klüver, Stefan Scholz, Jörg Matysik, A. Alia   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source