Results 41 to 50 of about 1,231,135 (287)

The toxicity of perfluoroalkyl acids in zebrafish (Danio rerio) [PDF]

, 2013
Perfluoroalkyl acids (PFAAs) are globally distributed synthetic chemicals. Their unique properties make them widely used, in industry and elsewhere. These are a group of compounds with varying carbon chain lengths and functional groups.
Ul Haq, Mazhar
core   +1 more source

Acute toxicological and behavioural effects of perfluorohexanoic acid (PFHxA) in the model nematode, Caenorhabditis elegans

Environmental Challenges
Perfluorohexanoic acid (PFHxA) has emerged as a significant environmental contaminant driven by the industrial transition to short-chain perfluoroalkyl substances.
Tanmoy Sana, Manjurul Islam Chowdhury, Panneerselvan Logeshwaran, Mallavarapu Megharaj   +3 more
doaj   +1 more source

BEHAVIOURAL, CHROMOSOMAL ABBERRATINS AND HEMATOLOGICAL CHANGES ASSOCIATED WITH ACUTE NITRITE TOXICITY IN AFRICAN VATFISH ‘CLARIAS GARIEPINUS’ [PDF]

Veterinary Medical Journal - Giza, 2005
This investigation presents the results of acute toxicity in Clarias gariepinus (C. gariepinus) exposed to median lethal dose of nitrite (58 mg/L) for 1, 2 and 4 days. The 96 hr  LC50 of nitrite for C. gariepinus was determined.
RANDA S. ISMAIL, AMANY A. ABBASS, HASNAA A. RADWAN   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Comparative behavioural toxicity of domoic acid and kainic acid in neonatal rats

, 2000
Cumulative behavioural toxicity was measured in groups of male and female rat pups (n=6/sex) at different stages of postnatal development. Dose-response curves (DRCs) for toxicity produced by domoic acid (DOM) were generated using animals on postnatal ...
T.A Doucette, G.V Allen, S.M Strain, C.L Ryan, R.A.R Tasker   +4 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Acute and sub-acute toxicity evaluation of dihydro-p-coumaric acid isolated from leaves of Tithonia diversifolia Hemsl. A. Gray in BALB/c mice

Frontiers in Pharmacology, 2022
In present study, the acute and sub-acute toxicities of Dihydro-p-coumaric acid isolated from the leaves of Tithonia diversifolia (Hemsl.) A. Gray was studied for safety issues in mammals.
Thiyam B. Devi, Thiyam B. Devi, Sarita Jena, Biswajit Patra, Kabrambam D. Singh, Saurabh Chawla, Vishakha Raina, Arunkumar Singh Koijam, Ajay Parida, Yallappa Rajashekar   +9 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles

IET Nanobiotechnology, 2021
Silicon dioxide nanoparticles (SiO2 NPs) are widely invested in medicine, industry, agriculture, consuming products, optical imaging agents, cosmetics, and drug delivery.
Bashir Jarrar, Amin Al‐Doaiss, Ali Shati, Mohammed Al‐Kahtani, Qais Jarrar   +4 more
doaj   +1 more source