Results 51 to 60 of about 1,029,768 (285)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Acute and sub-acute toxicity of aqueous extract of aerial parts of Caralluma dalzielii N. E. Brown in mice and rats

Heliyon, 2019
Caralluma dalzielii N. E. Brown (Asclepiadaceae) is a cactus-like shaped shrub widely used in traditional medicine for the treatment of rheumatoid arthritis, diabetes, infertility and impotence.
Chinenye Jane Ugwah-Oguejiofor, Charles Ogbonna Okoli, Michael Oguejiofor Ugwah, Millicent Ladi Umaru, Chiedozie Smart Ogbulie, Halilu Emmanuel Mshelia, Mohammed Umar, Anoka Ayembe Njan   +7 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Dynamic biospeckle analysis, a new tool for the fast screening of plant nematicide selectivity

Plant Methods, 2019
Background Plant feeding, free-living nematodes cause extensive damage to plant roots by direct feeding and, in the case of some trichodorid and longidorid species, through the transmission of viruses.
Felicity E. O’Callaghan, Roy Neilson, Stuart A. MacFarlane, Lionel X. Dupuy   +3 more
doaj   +1 more source

Effects of Lambda Cyhalothrin on the behaviour and histology of gills of Sarotherodon melanotheron in brackish water

Scientific African, 2019
Pyrethroids like Lambda Cyhalothrins, are synthetic insecticides that contaminate and modify the physico-chemical integrity of receiving water bodies and are toxic to the resident life forms.
Kelsy Alalibo, Ugbomeh Adaobi Patricia, Daka Erema Ransome   +2 more
doaj   +1 more source

Oral and dermal toxicity of alkenones extracted from Isochrysis species

Frontiers in Bioscience-Landmark, 2020
Isochrysis is commercially available marine algae used for animal feed, human nutrient supplements, and biodiesel. The Isochrysis species is one of five genera of haptophytes that produces unique, long-chain lipids known as alkenones that are promising ...
Kyle McIntosh, Jeffrey Sarver, Kristopher Mell, David J. Terrero, Charles R. Ashby Jr., Chris Reddy, Gregory O’ Neil, Jayachandra Babu Ramapuram, Amit K. Tiwari   +8 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Data for: Physicochemical characterization of Suvarna Bhasma, its toxicity profiling and behavioural assessment in zebrafish model

, 2019
Data File 1: Toxicity study in rat modelData File 2: Behavioural study in zebrafish ...
Bellare, J
core   +2 more sources

Size- and polymer-dependent effects of polystyrene and polyethylene micro- and nanoplastics in zebrafish (Danio rerio)

Ecotoxicology and Environmental Safety
Microplastics (MPs) have been extensively investigated, whereas nanoplastics (NPs) are increasingly recognized as emerging contaminants with potentially greater biological concern.
Valentina Perc, Victor Wepener, Urban Dajčman, Matej Hočevar, Damjana Drobne, Sara Novak   +5 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source