Results 71 to 80 of about 1,231,135 (287)

Acute toxicity and behavioural responses in Clarias batrachus (Linnaeus) exposed to herbicide pretilachlor

Heliyon, 2018
Pretilachlor is a systemic herbicide belonging to chloroacetamide group which is being used in rice fields for the control of annual weeds. The acute toxicity bioassay of pretilachlor was carried out by probit analysis method and the safe level was ...
Rakesh Soni, Sushant Kumar Verma
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Ecotoxicology and ecophysiology of mysids, with special reference to copper toxicity in Praunus flexuosus

, 2000
Toxicity of dissolved copper was examined in a common coastal mysid population {Praunusflexuosus}. The life cycle and ecophysiology were studied under natural conditions throughout the year, and responses to dissolved copper were determined in the ...
Garnacho, Eva
core   +1 more source

Impact of Amorphous Silica Nanoparticles on a Living Organism: Morphological, Behavioural and Molecular Biology Implications.

Frontiers in Bioengineering and Biotechnology, 2014
It is generally accepted that silica (SiO2) is not toxic. But the increasing use of silica nanoparticles (SiO2NPs) in many different industrial fields has prompted the careful investigation of its toxicity in biological systems.
Alfredo eAmbrosone, Maria Rosaria eScotto di Vettimo, Maria Ada eMalvindi, Roopin eModi, Oren eLevy, Marchesano eValentina, Pier Paolo ePompa, Claudia eTortiglione, Angela eTino   +8 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Effects of environmental concentrations of toxins BMAA and its isomers DAB and AEG on zebrafish larvae

Ecotoxicology and Environmental Safety
The increasing concern over the environmental presence of β-N-Methylamino-L-alanine (BMAA), a toxin primarily produced by cyanobacteria and diatoms, has stimulated numerous studies to evaluate the risk for exposed populations, mainly aquatic organisms ...
Jeanne Lichtfouse, Audrey Courtier, Annette C. Vergunst, Patrizia Giannoni   +3 more
doaj   +1 more source

Assessment of anxiolytic potential and acute toxicity study of Combretum micranthum G. Don. leaves (Combretaceae)

Journal of Medicinal Plants for Economic Development, 2020
Background: Combretum micranthum G. Don. (Combretaceae) is an ethnomedicinally valuable, undomesticated and indigenous shrub of West Africa.
Mohammed O. Amali, Soliu A. Atunwa, Quadri A. Omotesho, Eniola O. Oyedotun, Akeem I. Olapade   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source