Results 91 to 100 of about 1,029,768 (285)
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Postmodern Openings, 2017 This study provides information on how to identify a toxic workplace; identifies the types of toxic worker behavior, including abusive supervision and workplace mobbing; discusses how toxic workplaces affect employees at all levels; and describes how toxic workplaces can become hostile work environments.
openaire +2 more sources
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Mixture toxicity of pesticides and biological effects in agricultural streams [PDF]
, 2013 The main objective of this thesis was to examine pesticide mixture toxicity and its effects on aquatic biota in agricultural streams. This was accomplished by (1) calculating the ΣTUs for algae and Daphnia magna and a pesticide toxicity index (PTI) based
Rydh Stenström, Jenny
core +1 more source
ToxicsEndoperoxide-containing molecules based on the antimalarial drug artemisinin have demonstrated various biological properties, including modulation of calcium homeostasis.
Yaryna S. Buzan +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Ameliorating Effect of Chloride on Nitrite Toxicity to Freshwater Invertebrates with Different Physiology: a Comparative Study Between Amphipods and Planarians [PDF]
, 2008 High nitrite concentrations in freshwater ecosystems may cause toxicity to aquatic animals. These living organisms can take nitrite up from water through their chloride cells, subsequently suffering oxidation of their respiratory pigments (hemoglobin ...
Camargo, J.A., Alonso, A.
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Validating Well-Functioning Hepatic Organoids for Toxicity Evaluation
“Organoids”, three-dimensional self-organized organ-like miniature tissues, are proposed as intermediary models that bridge the gap between animal and human studies in drug development.
Tae Hee Kim +9 more
core +1 more source