Results 51 to 60 of about 812 (121)

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, Volume 183, Issue 15, Page 4321-4343, August 2026.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

Spectrofluorimetric method for atenolol determination based on gold nanoparticles

Acta Pharmaceutica, 2018
A simple and sensitive spectrofluorimetric method for determination of atenolol (ATE) using gold nanoparticles (AuNPs) was developed. The method is based on the quenching effect of atenolol on photoluminescence of AuNPs at λem = 705 nm.
Bakir Esam, Gouda Mohamed, Alnajjar Ahmed, Boraie Waleed E.   +3 more
doaj   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

A comparative study of ivabradine and atenolol in patients with moderate mitral stenosis in sinus rhythm

Indian Heart Journal, 2016
Background: Beta-blockers are frequently used in patients with mitral stenosis to control the heart rate and alleviate exercise-related symptoms. The objective of our study was to examine whether ivabradine was superior to atenolol for achieving higher ...
Gopalan Nair Rajesh, Kalathingathodika Sajeer, Chakanalil Govindan Sajeev, Cicy Bastian, Desabandhu Vinayakumar, Kader Muneer, Vellani Haridasan, Dolly Mathew, Biju George, Mangalath Narayanan Krishnan   +9 more
doaj   +1 more source

Pre‐anaesthetic risk assessment and management of dogs with myxomatous mitral valve disease: a spectrum of care narrative review

Journal of Small Animal Practice, Volume 67, Issue 8, Page 663-679, August 2026.
Myxomatous mitral valve disease, an acquired valvular degeneration, is the most common cardiac disorder in dogs, affecting approximately 10% of dogs in primary care veterinary practice. Dogs with myxomatous mitral valve disease frequently require anaesthesia for routine procedures.
I. Levinzon, L. Köster, E. Vettorato, A. H. Estrada   +3 more
wiley   +1 more source

Fluorinated Aminopiperidones as Non‐Glutarimide Thalidomide Analogs: Stereodivergent Synthesis and Validation

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Fluorinated aminopiperidones, designed as non‐glutarimide thalidomide analogs, were synthesized with full regio‐ and stereocontrol. The C*–CF3 used as carbonyl surrogate improved solubility and membrane interactions while abolishing cereblon binding.
Boštjan Adamlje, Tihomir Tomašič, Christian Steinebach, Sebastian Ebeling, Alexander Herrmann, Marcus D. Hartmann, Jessica L. Horner, Kinjal Bhadresha, Cindy H. Chau, William D. Figg, Izidor Sosič, Andrej Emanuel Cotman   +11 more
wiley   +1 more source

A possibility to interchange heart rate-slowing therapy with ivabradine and atenolol in patients with stable angina pectoris

Терапевтический архив, 2013
AIM: To evaluate the efficiency and safety of an interchange of atenolol and ivabradine in patients who had stable angina pectoris without myocardial infarction in the history and left ventricular (LV) systolic dysfunction/MATERIAL AND METHODS: The trial
A A Shavarov, G K Kiiakbaev, Zh D Kobalava   +2 more
doaj  

THE WAYS OF SYMPATHETIC SYSTEM OVERACTIVITY BLOCKING: RILMENIDINE VERSUS ATENOLOL

Рациональная фармакотерапия в кардиологии, 2016
Aim. To evaluate effects of long-term treatment with rilmenidine compared with atenolol on lipid and glucose metabolism and cardiovascular remodeling in hypertension. Material and methods.
Y. R. Kasherininov, E. K. Shavarova, A. A. Shavarov, N. V. Vachrameeva, A. N. Krutikov, E. V. Smirnova, A. O. Коnrady, E. V. Shlyakhto   +7 more
doaj   +1 more source

An investigation of the impact of atenolol on the risk of all-cause mortality in Asian individuals with hypertension and cardiovascular conditions

Bulletin of the National Research Centre
Background Despite several justifications for utilizing beta-blockers, such as atenolol, as the initial treatment for hypertension in the presence of cardiovascular disease, some studies have demonstrated that calcium channel blockers were more effective
Abdullah Alkattan, Eman Alsalameen, Alaa Harmoush, Mhd Nour Farawati, Hind Alsharif, Nagla Mahmoud, Mhd Ali Farawati, Amjad Alfaleh, Mahmoud Kandeel, Nashwa Radwan   +9 more
doaj   +1 more source

A meta-analytical comparison of atenolol with angiotensin-converting enzyme inhibitors on arterial stiffness, peripheral blood pressure and heart rate in hypertensive patients

Clinical and Experimental Hypertension, 2017
Objectives: This meta-analysis of randomized parallel controlled trials was designed to compare the efficacy of atenolol with angiotensin-converting enzyme inhibitors (ACEIs) in changing pulse wave velocity (PWV), peripheral blood pressure and heart rate
Hong Xie, Gaoqing Luo, Yong Zheng, Feng Peng, Liangdi Xie   +4 more
doaj   +1 more source