Discover OncologyBackground Pancreatic cancer-associated fibroblasts (CAFs) play a crucial role in tumor progression and immune evasion. Asperuloside (ASP) is an iridoid glycoside with potential anti-tumor properties.
Ling-zhi Cao +5 more
doaj +1 more source
ERVW-1 Activates ATF6-Mediated Unfolded Protein Response by Decreasing GANAB in Recent-Onset Schizophrenia [PDF]
, 2023 Xing Xue +4 more
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Understanding the Role of Phosphoinositide 3-Kinase and its Function as a Driving Force behind the ER Stress Response in Fibrostenotic Crohn’s Disease-affected Ileal Smooth Muscle Cells [PDF]
, 2018 Crohn’s disease (CD) affects about 780,000 people in the United States alone, and it is estimated that 6-15 per 100,000 persons will receive a diagnosis of this disease each year.
Yadav, Prashant
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BiP, GRP94, calreticulin and calnexin contribute to development of the notochord in medaka fish
Cell Structure and FunctionThe accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to maintain the homeostasis of the ER. The UPR consists of the IRE1, PERK and ATF6 pathways in vertebrates. Knockout of the
Serina Kita +2 more
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Yap Regulates ATF6-Mediated Unfolded Protein Response [PDF]
, 2015 Hippo信号通路最早在果蝇里发现，是在进化上高度保守的一条激酶级联的通路，当Hippo通路的缺失会造其下游调控因子Yap或Taz的激活，促进细胞增殖，抑制细胞凋亡，从而导致器官增大和肿瘤产生。此外，大量文献阐述了内质网压力和肿瘤产生具有相关性。本实验室研究表明，Hippo通路的缺失或Yap蛋白的激活会引起内质网应激信号通路的激活和内质网的增大，并通过内质网应激反应导致肝脏器官增大和肿瘤生成。 当Hippo激酶，在高等动物的同源物为Mst1和Mst2激酶的缺失或Yap激活时 ...
蔡亚波
core
Luteolin mitigates doxorubicin-induced hepatotoxicity and neurotoxicity: modulating the liver–brain axis via IRE1α/GRP78/ATF6 endoplasmic reticulum stress pathways and miRNA-199a-5p expression [PDF]
Rasha D. Abdrabou +3 more
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The Role of GRP78/ATF6/IRE1 and Caspase-12 Signaling Pathways in the Protective Effects of n-Hexane Oil Extract of Black Soldier Flies’ Larvae (<i>Hermetia illucens</i>) Against Aflatoxin-Induced Hepatotoxicity in Rats [PDF]
Fateme Heidari +2 more
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Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors [PDF]
, 2021 Nnejiuwa U. Ibe +2 more
openalex +1 more source