Results 91 to 100 of about 283,363 (298)

What Is the Added Value of Carotid CEUS in the Characterization of Atherosclerotic Plaque?

Medicina
Background and Objectives: Unstable atherosclerotic plaque in the arteries is one of the main risk factors for cerebral ischemia. Duplex ultrasound is a frequently used diagnostic method, but it has some limitations for microvascularization and ...
Andrejs Lioznovs, Maija Radzina, Laura Saule, Peteris Einars Grinbergs, Aigars Lacis   +4 more
doaj   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Common carotid intima media thickness and ankle-brachial pressure index correlate with local but not global atheroma burden:a cross sectional study using whole body magnetic resonance angiography [PDF]

, 2014
Common carotid intima media thickness (CIMT) and ankle brachial pressure index (ABPI) are used as surrogate marker of atherosclerosis, and have been shown to correlate with arterial stiffness, however their correlation with global atherosclerotic burden ...
Belch, Jill J. F.; id_orcid, Belch, Jill J F, Faisel Khan, Stephen J Gandy, Gardner, Michael, Weir-McCall, Jonathan R., Rauchhaus, Petra, Adamson, Carly L., Gandy, Stephen J., Gandy Stephen J., Morris, Andrew D., Rauchhaus Petra, Houston, J. Graeme, Allan D Struthers, Lambert, Matthew A., Matthew A Lambert, J Graeme Houston, Ramkumar Prasad Guntur, Struthers Allan D., Lambert Matthew A., Gardner Michael, Adamson Carly L., Jill J F Belch, Michael Gardner, Khan, Faisel; id_orcid, Petra Rauchhaus, Weir-McCall Jonathan R., Jonathan R Weir-McCall, Khan Faisel, Ramkumar, Prasad Guntur, Khan, Faisel, Belch Jill J. F., Morris Andrew D., Carly L Adamson, Struthers, Allan D., Houston J. Graeme, Andrew D Morris, Prasad Guntur Ramkumar   +37 more
core   +2 more sources

Animal stroke models and outcome evaluation: A review

Animal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba, Helen M. Atkinson, Anthony K. C. Chan   +2 more
wiley   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Neovascularization in Atherosclerotic Plaques: Clinical Implications, Detection, and Prevention Strategies

Reviews in Cardiovascular Medicine
Following the global increase in atherosclerotic cardiovascular diseases, the demand for the effective identification of high-risk factors that lead to atherosclerotic plaque rupture and the search for new therapeutic targets has also increased ...
Long Zhang, Chancui Deng, Sha Wang, Bei Shi, Guanxue Xu   +4 more
doaj   +1 more source

Atherosclerotic plaque vulnerability as an explanation for the increased risk of stroke in elderly undergoing carotid artery stenting [PDF]

, 2011
Background and Purpose-Recent randomized trials showed an increased periprocedural risk for stroke with increasing age in patients undergoing carotid artery stenting.
de Borst, G.J., de Kleijn, D.P.V., Gert Jan de Borst, Michiel L. Bots, Reichmann, B.L., de Vries, J.P.P.M., Guus W. van Lammeren, Bots, M.L., Gerard Pasterkamp, Boudewijn L. Reichmann, Frans L. Moll, Dominique P.V. de Kleijn, Jean-Paul P.M. de Vries, Moll, F.L., Pasterkamp, G., van Lammeren, G.W.   +15 more
core   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source