Results 41 to 50 of about 154,772 (354)

Vulnerable Plaque, Characteristics, Detection, and Potential Therapies

Journal of Cardiovascular Development and Disease, 2019
Plaque development and rupture are hallmarks of atherosclerotic vascular disease. Despite current therapeutic developments, there is an unmet necessity in the prevention of atherosclerotic vascular disease. It remains a challenge to determine at an early
Anouar Hafiane
doaj   +1 more source

Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe–/– mice

Molecular Metabolism, 2021
Objective: Interferon regulatory factor (IRF) 5 is a transcription factor known for promoting M1 type macrophage polarization in vitro. Given the central role of inflammatory macrophages in promoting atherosclerotic plaque progression, we hypothesize ...
Julia Leipner, Tsai-Sang Dederichs, Alexander von Ehr, Simon Rauterberg, Carolin Ehlert, Julian Merz, Bianca Dufner, Natalie Hoppe, Katja Krebs, Timo Heidt, Constantin von zur Muehlen, Peter Stachon, Klaus Ley, Dennis Wolf, Andreas Zirlik, Christoph Bode, Ingo Hilgendorf, Carmen Härdtner   +17 more
doaj   +1 more source

Resolution of Occlusive Carotid Artery Thrombus Treated with Anticoagulation as Demonstrated on Duplex Ultrasonography. [PDF]

, 2017
BACKGROUND AND PURPOSE: While the majority of cerebral ischemic events due to carotid occlusive disease result from atherosclerotic plaque rupture, intraluminal carotid artery thrombus occasionally occurs in patients without preexisting carotid ...
Liang, John W., Stein, Laura, Weinberger, Jesse   +2 more
core   +2 more sources

Ultra-short echo time cardiovascular magnetic resonance of atherosclerotic carotid plaque. [PDF]

, 2010
BACKGROUND: Multi-contrast weighted cardiovascular magnetic resonance (CMR) allows detailed plaque characterisation and assessment of plaque vulnerability.
Boyle, JJ, Chan, CF, Firmin, DN, Gatehouse, P, Keenan, NG, Nielles-Vallespin, S, Pennell, DJ, Sheppard, MN   +7 more
core   +2 more sources

Gene deficiency in activating Fcγ receptors influences the macrophage phenotypic balance and reduces atherosclerosis in mice [PDF]

, 2013
Immunity contributes to arterial inflammation during atherosclerosis. Oxidized low-density lipoproteins induce an autoimmune response characterized by specific antibodies and immune complexes in atherosclerotic patients.
Egido, J., Gomez-Guerrero, C., Lazaro, I., Lopez-Franco, O., Lopez-Parra, V., Lutgens, E., Mallavia, B., Oguiza, A., Ortiz-Muñoz, G., Recio, C.   +9 more
core   +5 more sources

Association between weight-adjusted waist index and carotid atherosclerotic plaque in patients with type 2 diabetes in the Chinese population

Diabetology & Metabolic Syndrome
Purpose The purpose of this study is to investigate the relationship between the weight-adjusted waist index (WWI) and the incidence of carotid atherosclerotic plaque in patients with type 2 diabetes (T2DM) in the Chinese population.
Yu Qin, Jing-Jing Ye, Xu-Nan Wu, Yue Xia, Hao-Xiang Li, Ling Yang, Xia Deng, Guo-Yue Yuan   +7 more
doaj   +1 more source

Platelet‐Mimicking Therapeutic System for Noninvasive Mitigation of the Progression of Atherosclerotic Plaques

Advanced Science, 2021
Atherosclerotic plaque is the primary cause of cardiovascular disorders and remains a therapeutic hurdle for the early intervention of atherosclerosis. Traditional clinical strategies are often limited by surgery‐related complications or unsatisfactory ...
Yi Ma, Yuxuan Ma, Mengqiu Gao, Zhihao Han, Wen Jiang, Yueqing Gu, Yi Liu   +6 more
doaj   +1 more source

Natriuretic peptide receptor-C is up-regulated in the intima of advanced carotid artery atherosclerosis [PDF]

, 2016
OBJECTIVE: Natriuretic peptide receptor-C (NPR-C/NPR-3) is a cell surface protein involved in vascular remodelling that is up-regulated in atherosclerosis. NPR-C expression has not been well characterized in human carotid artery occlusive lesions.
Abendschein, Dana R, Detering, Lisa, Harring, Scott D, Liu, Yongjian, Lu, Dongsi, Vemuri, Chandu, Woodard, Pamela K, Zayed, Mohamed A   +7 more
core   +3 more sources

Improved detection of molecular markers of atherosclerotic plaques using sub-millimeter PET imaging [PDF]

, 2020
Since atherosclerotic plaques are small and sparse, their non-invasive detection via PET imaging requires both highly specific radiotracers as well as imaging systems with high sensitivity and resolution.
Bormans, Guy, Bridoux, Jessica, Broisat, Alexis, Caveliers, Vicky, Cleeren, Frederik, Debie, Pieterjan, Descamps, Benedicte, Devoogdt, Nick, Hernot, Sophie, Neyt, Sara, Vanhove, Christian, Xavier, Catarina   +11 more
core   +2 more sources

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source