Results 41 to 50 of about 146,166 (354)

Proteomic analysis of atherosclerotic plaque

Biomedicine & Pharmacotherapy, 2010
Proteins play a fundamental role in the formation and progression of plaque, but proteomic analysis of plaque as a whole is difficult, due to its heterogeneous cellular composition and an abundance of plasma proteins. Several approaches to this problem are reported in the literature; they include proteomic analysis of vascular tissues, analysis of ...
PORCELLI B., CIARI I., FELICI C., PAGANI R., BANFI C., BRIOSCHI M., GIUBBOLINI M., DE DONATO G., SETACCI C., TERZUOLI L.   +9 more
openaire   +6 more sources

Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model

BMC Cardiovascular Disorders, 2012
Background This study characterizes the distribution and components of plaque structure by presenting a three-dimensional blood-vessel modelling with the aim of determining mechanical properties due to the effect of lipid core and calcification within a ...
Wong Kelvin KL, Thavornpattanapong Pongpat, Cheung Sherman CP, Sun Zhonghua, Tu Jiyuan   +4 more
doaj   +1 more source

Oral glucose tolerance test predicts increased carotid plaque burden in patients with acute coronary syndrome. [PDF]

PLoS ONE, 2017
Type 2 diabetes and prediabetes are established risk factors for atherosclerosis. The aim of this study was to evaluate the atherosclerotic plaque burden in the carotid arteries of patients with acute coronary syndrome according to their glycemic status ...
Thorarinn A Bjarnason, Steinar O Hafthorsson, Linda B Kristinsdottir, Erna S Oskarsdottir, Thor Aspelund, Sigurdur Sigurdsson, Vilmundur Gudnason, Karl Andersen   +7 more
doaj   +1 more source

Machine Learning Framework to Identify Individuals at Risk of Rapid Progression of Coronary Atherosclerosis: From the PARADIGM Registry. [PDF]

, 2020
Background Rapid coronary plaque progression (RPP) is associated with incident cardiovascular events. To date, no method exists for the identification of individuals at risk of RPP at a single point in time.
Al'Aref, Subhi J, Andreini, Daniele, Baskaran, Lohendran, Bax, Jeroen J, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Choi, Jung Hyun, Chun, Eun Ju, Conte, Edoardo, de Araújo Gonçalves, Pedro, Gottlieb, Ilan, Gransar, Heidi, Hadamitzky, Martin, Han, Donghee, Kim, Yong-Jin, Kolli, Kranthi K, Lee, Byoung Kwon, Lee, Sang-Eun, Leipsic, Jonathon A, Lin, Fay Y, Maffei, Erica, Marques, Hugo, Min, James K, Narula, Jagat, Pontone, Gianluca, Raff, Gilbert L, Samady, Habib, Shaw, Leslee J, Shin, Sangshoon, Stone, Peter, Sung, Ji Min, van Rosendael, Alexander R, Virmani, Renu   +35 more
core  

Desipramine enhances the stability of atherosclerotic plaque in rabbits monitored with molecular imaging.

PLoS ONE, 2023
Acid sphingomyelinase (ASM) promotes atherogenesis and acute cardiovascular events. We previously demonstrated ASM inhibitor desipramine attenuated oxidized-LDL-induced macrophage apoptosis in vitro.
Min Zhao, Baiyang You, Xiaole Wang, Jin Huang, Ming Zhou, Ruizheng Shi, Guogang Zhang   +6 more
doaj   +2 more sources

Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques [PDF]

, 2010
Background: In most models of experimental thrombosis, healthy blood vessels are damaged. This results in the formation of a platelet thrombus that is stabilized by ADP signaling via P2Y(12) receptors.
J. J. J. van Giezen, Johan W. M. Heemskerk, Judith M. E. M. Cosemans, Marijke J. E. Kuijpers, Marion A. H. Feijge, Mirjam G. A. oude Egbrink, Paola E. J. van der Meijden, Reyhan Nergiz-Unal, Robert F. Storey, Yu Wang   +9 more
core   +9 more sources

3D Fiber Orientation in Atherosclerotic Carotid Plaques [PDF]

, 2017
Atherosclerotic plaque rupture is the primary trigger of fatal cardiovascular events. Fibrillar collagen in atherosclerotic plaques and their directionality are anticipated to play a crucial role in plaque rupture.
Akyildiz, A.C. (Ali), Baaijens, F.P.T. (Frank), Chai, C.-K. (Chen-Ket), Gijsen, F.J.H. (Frank), Lugt, A. (Aad) van der, Oomens, C.W.J. (Cees), Strijkers, G.J. (Gustav)   +6 more
core   +3 more sources

Chromosomal alterations in atherosclerotic plaques

Atherosclerosis, 2001
Alterations of chromosomes 7 and 11 have been involved in the progression of atherosclerosis. Twenty-three carotid endarterectomy specimens were studied for the presence of alterations in chromosomes 7 and 11, and fibroblastic growth factor-3 (FGF-3) gene amplification.
L. Matturri, A. Cazzullo, P. Turconi, A.M. Lavezzi, P. L. Vandone, L. Gabrielli, G. Fernández Alonso, D. Grana, J. Milei   +8 more
openaire   +4 more sources

Comparison of cardiovascular biomarker expression in extracellular vesicles, plasma and carotid plaque for the prediction of MACE in CEA patients

Scientific Reports, 2023
Extracellular vesicles (EV) are a novel biomarker source for diagnosis and prognosis of cardiovascular disease. A protein comparison of plasma EVs in relation to blood plasma and atherosclerotic plaque has not been performed but would provide insight ...
Maarten C. Verwer, Joost Mekke, Nathalie Timmerman, Farahnaz Waissi, Arjan Boltjes, Gerard Pasterkamp, Gert J. de Borst, Dominique P. V. de Kleijn   +7 more
doaj   +1 more source

Orthopedic surgery increases atherosclerotic lesions and necrotic core area in ApoE-/- mice [PDF]

, 2016
Background and aims Observational studies show a peak incidence of cardiovascular events after major surgery. For example, the risk of myocardial infarction increases 25-fold early after hip replacement.
Chen, Cohen, Corrales-Medina, Dutta, Dutta, Gualandro, Hans W.M. Niessen, Hanson, Ilse P.A. Zethof, Janssen, Kaynar, King, Kleemann, Lalmohamed, Landesberg, Lars F.H. Theyse, Libby, Martine C. Morrison, Moore, Morrison, Naghavi, Paul A.J. Krijnen, Reid, Rianne van der Linden, Robert Kleemann, Santos-Gallego, Santos-Gallego, Santos-Gallego, Seimon, Smeeth, Tan, Thompson, Thompson, Van der Donckt, van Dijk, Virmani, Virmani, Wessel W. Fuijkschot, Yvo M. Smulders, Zhang   +39 more
core   +1 more source