Results 51 to 60 of about 283,363 (298)

Macrophage heterogeneity in atherosclerotic plaques [PDF]

Current Opinion in Lipidology, 2009
The varied behaviour of macrophages and foam cells during atherosclerosis and its clinical sequelae prompt the question whether all these activities can be the property of a single cell population.Subsets of monocytes with distinct patterns of surface markers and behaviours during inflammation have recently been characterized and shown to have ...
Johnson, JL, Newby, AC
openaire   +3 more sources

Systemic Extracerebral Atherosclerotic Burden and Dementia Risk After Incident Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke survivors are at increased risk of dementia, but clinically accessible markers of risk heterogeneity remain limited. Previous studies have largely examined atherosclerotic disease in individual vascular beds rather than the overall burden of systemic extracerebral atherosclerosis.
Zhexuan Yu, Tianxue Chen, Wei Jin, Weifeng Jin, Haitong Wan   +4 more
wiley   +1 more source

Cellular and molecular components of the atherosclerotic process: Primary colture and characterization of human vascular smooth muscle cells from carotid artery [PDF]

, 2009
Introduction The last years were characterized by several studies proceeding to understand SMC heterogeneity. Animal models of rat or rabbit IT after endothelial lesion are presently the most studied models for atherosclerotic plaque formation and ...
Gagliano, Teresa
core  

Microvascular Damage Is Associated With Carotid Wall Structural Changes in Systemic Sclerosis: A Capillaroscopy and Ultrasound‐Based Observational Study

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by cardiovascular risk excess not fully explained by traditional factors. Whether the severity of microvascular damage correlates with structural subclinical atherosclerosis remains unclear. We investigated the relationship between nailfold videocapillaroscopy (NVC) abnormalities and carotid ...
Eugenio Capparelli, Luca Clerici, Francesco Lapia, Giusy C. Moltisanti, Eleonora Zaccara, Greta Pellegrino, Daniela Bompane, Francesca Capelli, Letizia Ferrami, Laura Castelnovo, Antonio Tamburello, Maria Sole Chimenti, Paola Faggioli, Antonino Mazzone   +13 more
wiley   +1 more source

Mechanisms of erosion of atherosclerotic plaques [PDF]

Current Opinion in Lipidology, 2017
Purpose of review The present review explores the mechanisms of superficial intimal erosion, a common cause of thrombotic complications of atherosclerosis. Recent findings Human coronary artery atheroma that give rise to thrombosis because of erosion differ diametrically from those ...
Thibaut, Quillard, Grégory, Franck, Thomas, Mawson, Eduardo, Folco, Peter, Libby   +4 more
openaire   +2 more sources

oxLDL downregulates the dendritic cell homing factors CCR7 and CCL21 [PDF]

, 2012
Dendritic cells (DCs) and oxLDL play an important role in the atherosclerotic process with DCs accumulating in the plaques during plaque progression.
Korbinian Lackermair, Kopp, Reinhard, Beiras-Fernandez, Andres, Kaczmarek, Ingo, Summo, Claudia, Andres Beiras-Fernandez, Weis, Michael, Robert David, Michael Weis, Marius Lambert, Thomas Nickel, Ingo Kaczmarek, Claudia Summo, Sicic, Zeljka, Georgios Meimarakis, Lackermair, Korbinian, Lambert, Marius, Nickel, Thomas, Susanne Pfeiler, Pfeiler, Susanne, Meimarakis, Georgios, Reinhard Kopp, Lackermair, Korbinian Johannes, Beiras Fernández, Andrés, Zeljka Sicic, David, Robert   +25 more
core   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation[S]

Journal of Lipid Research, 2013
Lysophosphatidic acid (LPA), a bioactive lysophospholipid, accumulates in the atherosclerotic plaque. It has the capacity to activate mast cells, which potentially exacerbates plaque progression.
Martine Bot, Saskia C.A. de Jager, Luke MacAleese, H. Maxime Lagraauw, Theo J.C. van Berkel, Paul H.A. Quax, Johan Kuiper, Ron M.A. Heeren, Erik A.L. Biessen, Ilze Bot   +9 more
doaj   +1 more source

Coronary Atherosclerosis Imaging

Diagnostics, 2020
Identifying patients at increased risk of coronary artery disease, before the atherosclerotic complications become clinically evident, is the aim of cardiovascular prevention.
Michael Y. Henein, Sergio Vancheri, Gani Bajraktari, Federico Vancheri   +3 more
doaj   +1 more source

Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice. [PDF]

PLoS ONE, 2013
The granzyme B/perforincytotoxic pathway is a well established mechanism of initiating target cell apoptosis. Previous studies have suggested a role for the granzyme B/perforin cytotoxic pathway in vulnerable atherosclerotic plaque formation.
Paul R Hiebert, Wendy A Boivin, Hongyan Zhao, Bruce M McManus, David J Granville   +4 more
doaj   +1 more source