Results 61 to 70 of about 957,277 (312)

Análisis de la implementación de una Política Pública Educativa utilizando la herramienta Atlas Ti

miradas (Pereira), 2022
Una política pública se genera de la necesidad de modificar una situación problema identificada en una sociedad, por medio de acciones tomadas desde un ente gubernamental (Deubel, 2002) en Colombia en el año 2015 se planteó la Política de Día de la Excelencia como respuesta a la necesidad de mejorar los resultados académicos y alcanzar el objetivo de ...
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Quantification et bilan de matiere de la reaction clinopyroxene-spinelle lors de la formation du plagioclase dans les lherzolites a spinelle

Estudios Geologicos, 1998
La formación de plagioclasa sódica (Pl) y de vidrio en las peridotitas de Saghro (Anti-Atlas marroquí) y de La Palma (Islas Canarias) se puede explicar como resultado de un proceso de metasomatismo y de fusión parcial de climpyroxeno (Cpx) y espinela ...
A. Ibhi, H. Nachit, M. Berrahma, H. Abia, J. Hernández   +4 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Fiducial polarization observables in hadronic WZ production: A next-to-leading order QCD+EW study

, 2019
We present a study at next-to-leading-order (NLO) of the process $pp \to W^\pm Z \to \ell \nu_l \ell'^+ \ell'^-$, where $\ell,\ell' =e, \mu$, at the Large Hadron Collider.
Baglio, Julien, Ninh, LE Duc
core   +1 more source

Performance of temperature and radiation index models for point-scale snow water equivalent (SWE) simulations in the Moroccan High Atlas Mountains

Hydrological Sciences Journal, 2018
Four models of increasing complexity were tested and compared to simulate snow water equivalent at the local scale in the Moroccan High Atlas range. A classical temperature index model (TI) and three enhanced temperature index models that respectively ...
H. Bouamri, A. Boudhar, S. Gascoin, C. Kinnard   +3 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

PSACNN: Pulse Sequence Adaptive Fast Whole Brain Segmentation

, 2019
With the advent of convolutional neural networks~(CNN), supervised learning methods are increasingly being used for whole brain segmentation. However, a large, manually annotated training dataset of labeled brain images required to train such supervised ...
Fischl, Bruce, Greve, Douglas N., Hoopes, Andrew, Jog, Amod, Van Leemput, Koen   +4 more
core   +1 more source