Results 61 to 70 of about 634,659 (335)

Physical twinning for joint encoding-decoding optimization in computational optics: a review

Light: Science & Applications
Computational optics introduces computation into optics and consequently helps overcome traditional optical limitations such as low sensing dimension, low light throughput, low resolution, and so on.
Liheng Bian, Xinrui Zhan, Rong Yan, Xuyang Chang, Hua Huang, Jun Zhang   +5 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Large-scale scattering-augmented optical encryption

Nature Communications
Data proliferation in the digital age necessitates robust encryption techniques to protect information privacy. Optical encryption leverages the multiple degrees of freedom inherent in light waves to encode information with parallel processing and ...
Liheng Bian, Xuyang Chang, Shaowei Jiang, Liming Yang, Xinrui Zhan, Shicong Liu, Daoyu Li, Rong Yan, Zhen Gao, Jun Zhang   +9 more
doaj   +1 more source

Answer-Type Modification without Tears: Prompt-Passing Style Translation for Typed Delimited-Control Operators

, 2016
The salient feature of delimited-control operators is their ability to modify answer types during computation. The feature, answer-type modification (ATM for short), allows one to express various interesting programs such as typed printf compactly and ...
Kameyama, Yukiyoshi, Kiselyov, Oleg, Kobori, Ikuo   +2 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Air Traffic Safety: continued evolution or a new Paradigm. [PDF]

, 2007
The context here is Transport Risk Management. Is the philosophy of Air Traffic Safety different from other modes of transport? – yes, in many ways, it is.
Brooker, Peter
core  

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Near-Space Communications: The Last Piece of 6G Space–Air–Ground–Sea Integrated Network Puzzle

Space: Science & Technology
This article presents a comprehensive study on the emerging near-space communications (NS-COM) within the context of space–air–ground–sea integrated network (SAGSIN).
Hongshan Liu, Tong Qin, Zhen Gao, Tianqi Mao, Keke Ying, Ziwei Wan, Li Qiao, Rui Na, Zhongxiang Li, Chun Hu, Yikun Mei, Tuan Li, Guanghui Wen, Lei Chen, Zhonghuai Wu, Ruiqi Liu, Gaojie Chen, Shuo Wang, Dezhi Zheng   +18 more
doaj   +1 more source

Chemical inhibition of DNA repair kinases as a promising tool in oncology

Biomedical Papers, 2016
Background: DNA repair pathways play a major role in tumour resistance towards chemo- and radiotherapy. Therefore, inhibitors of specific DNA repair pathways might be advantageous when used in combination with DNA-damaging agents, such as ionizing ...
Kamila Durisova, Barbora Salovska, Jaroslav Pejchal, Ales Tichy   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source