Results 41 to 50 of about 290,490 (248)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

An Ionospheric Anomaly Monitor Based on the One Class Support Vector Algorithm for the Ground-Based Augmentation System

Remote Sensing, 2021
An ionospheric anomaly is the irregular change of the ionosphere. It may result in potential threats for the ground-based augmentation system (GBAS) supporting the high-level precision approach.
Zhen Gao, Kun Fang, Yanbo Zhu, Zhipeng Wang, Kai Guo   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Avaliação das propostas de integração IP sobre ATM [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência da Computação.ATM (Asynchronous Transfer Mode) é uma das tecnologias de rede de alta velocidade mais adotada nos dias atuais, sendo ...
Saraiva, Jackson Alves
core  

Availability evaluation and optimisation of advanced receiver autonomous integrity monitoring fault detection and exclusion considering temporal correlations

IET Radar, Sonar & Navigation
The Advanced Receiver Autonomous Integrity Monitoring (ARAIM) provides an Aircraft‐Based Augmentation System function for aircraft Global Navigation Satellite System equipment.
Jingtian Du, Kun Fang, Zhipeng Wang, Yanbo Zhu   +3 more
doaj   +1 more source

An Error Overbounding Method Based on a Gaussian Mixture Model with Uncertainty Estimation for a Dual-Frequency Ground-Based Augmentation System

Remote Sensing, 2022
To ensure the integrity of a ground-based augmentation system (GBAS), an ionosphere-free (Ifree) filtering algorithm with dual-frequency measurements is employed to make the GBAS free of the first-order ionospheric influence. However, the Ifree algorithm
Zhen Gao, Kun Fang, Zhipeng Wang, Kai Guo, Yuan Liu   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Physical twinning for joint encoding-decoding optimization in computational optics: a review

Light: Science & Applications
Computational optics introduces computation into optics and consequently helps overcome traditional optical limitations such as low sensing dimension, low light throughput, low resolution, and so on.
Liheng Bian, Xinrui Zhan, Rong Yan, Xuyang Chang, Hua Huang, Jun Zhang   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source