Results 21 to 30 of about 135,876 (264)
Mercury: An open-source simulator for the evaluation of air transport mobility
European Journal of Transport and Infrastructure ResearchThe Mercury simulator, a performance assessment platform, is a stochastic, agent-based model developed over several years during research projects. It features a detailed description of the air transportation system at the European level, including ...
Luis Delgado +4 more
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When heat casts a spell on the DNA damage checkpoints [PDF]
Open Biology, 2014 Peregrine Laziosi (1265–1345), an Italian priest, became the patron saint of cancer patients when the tumour in his left leg miraculously disappeared after he developed a fever. Elevated body temperature can cause tumours to regress and sensitizes cancer
Thomas Turner, Thomas Caspari
doaj +1 more source
Applied SciencesLarge Language Models (LLMs), based on their highly developed ability to comprehend and generate human-like text, promise to revolutionize all aspects of society.
Sebastian Wandelt +4 more
doaj +1 more source
THE IMPACT OF BANKING NETWORK SERVICES THROUGH PROFITABILITY ON INDONESIA BANKING COMPANIES
Economy and Sociology, 2020 The banking sector has embraced the use of technology to serve its clients faster and also to do more with less. Emerging technologies have changed the banking industry from paper and branch based banks to digitized and networked banking services.
Euphrasia Susy SUHENDRA +3 more
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A review of trends and patterns in transportation journals from 2000 to 2024
Transportation Research Interdisciplinary PerspectivesThis study addresses the need to understand trends, thematic shifts, and emerging areas in transportation research, given the increasing number of journals in the field.
Sebastian Wandelt +2 more
doaj +1 more source
EnergiesWater Supply and Distribution Networks (WSDNs) offer underexplored potential for energy recovery. While many studies confirm their technical feasibility, few assess the long-term operational compatibility and economic viability of such solutions.
François Nuc, Patrick Hendrick
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Redox Report, 2021 Objectives: High dose-rate ionizing radiation (IR) causes severe DSB damage, as well as reactive oxygen species (ROS) accumulation and oxidative stress.
Qingmei Meng +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source