Results 31 to 40 of about 172,362 (251)

Chemical inhibition of DNA repair kinases as a promising tool in oncology

Biomedical Papers, 2016
Background: DNA repair pathways play a major role in tumour resistance towards chemo- and radiotherapy. Therefore, inhibitors of specific DNA repair pathways might be advantageous when used in combination with DNA-damaging agents, such as ionizing ...
Kamila Durisova, Barbora Salovska, Jaroslav Pejchal, Ales Tichy   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Submission to CAC

Communications, 2004
Asynchronous transfer mode (ATM) is the base for future telecommunication network. The greatly variable requirements for different applications, especially in video and data traffic, make high demands on the development of traffic control in ATM networks.
Peter Kvackaj, Ivan Baronak
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

A Machine Learning Framework for Predicting and Resolving Complex Tactical Air Traffic Events Using Historical Data

Aerospace
One of the key functions of Air Traffic Management (ATM) is to balance airspace capacity and demand. Despite measures that are taken during the strategic and pre-tactical phases of flight, demand–capacity imbalances still occur in flight, often ...
Anthony De Bortoli, Cynthia Koopman, Leander Grech, Remi Zaidan, Didier Berling, Jason Gauci   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

SpectraTrack: megapixel, hundred-fps, and thousand-channel hyperspectral imaging

Nature Communications
Hyperspectral imaging (HSI) finds broad applications in various fields due to its substantial optical signatures for the intrinsic identification of physical and chemical characteristics.
Daoyu Li, Jinxuan Wu, Jiajun Zhao, Hanwen Xu, Liheng Bian   +4 more
doaj   +1 more source

Neurophysiological Vigilance Characterisation and Assessment: Laboratory and Realistic Validations Involving Professional Air Traffic Controllers

Brain Sciences, 2020
Vigilance degradation usually causes significant performance decrement. It is also considered the major factor causing the out-of-the-loop phenomenon (OOTL) occurrence.
Marika Sebastiani, Gianluca Di Flumeri, Pietro Aricò, Nicolina Sciaraffa, Fabio Babiloni, Gianluca Borghini   +5 more
doaj   +1 more source

Lufthansa Express Rail in Germany: A critical evaluation of benefits and limitations of the intermodal network based on journey time and fares

Multimodal Transportation, 2022
Frankfurt Airport is a role model for intermodal infrastructure, given its excellent degree of air, rail, and road connectivity. The connection Cologne-Frankfurt, for instance, is frequently used as the prime example for air-rail mode substitution, where
Sebastian Wandelt, Xiaoqian Sun
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source