Results 141 to 150 of about 1,246,781 (254)

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

A Submesoscale Cascade‐Driven Mesoscale Seasonal Cycle in the Subtropics

Geophysical Research Letters
We show that the submesoscale inverse cascade almost entirely drives the mesoscale kinetic energy (KE) seasonal cycle in the interior subtropical gyre.
Ling Feng, Kaushik Srinivasan, James C. McWilliams, Pierre Damien, Roy Barkan, Chuanyu Liu, Fan Wang   +6 more
doaj   +1 more source

Worsening drought of Nile basin under shift in atmospheric circulation, stronger ENSO and Indian Ocean dipole. [PDF]

Sci Rep, 2022
Mahmoud SH, Gan TY, Allan RP, Li J, Funk C.   +4 more
europepmc   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

The atmospheric circulation patterns during dry periods in Lithuania

Oceanologia, 2014
This paper reveals the atmospheric circulation patterns during dry periods in Lithuania.~The research covers the period from 1961 to 2010. Atmospheric circulation features were analysed using the Hess and Brezowski classification of macro-circulation ...
Egidijus Rimkus, Justas Kažys, Donatas Valiukas   +2 more
doaj  

Limited Hysteresis in the Atmospheric Dynamics of Hot Jupiters

The Astrophysical Journal
Over the past two decades, a coherent picture has emerged of the atmospheric dynamics of hot Jupiters from a combination of three-dimensional general circulation models and astronomical observations.
Thaddeus D. Komacek
doaj   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

The atmospheric circulation patterns during dry periods in Lithuania** The study was supported by the Lithuanian-Swiss cooperation programme to reduce economic and social disparities within the enlarged European Union under project agreement No. CH-3-ŠMM-01/05.

Oceanologia, 2014
This paper reveals the atmospheric circulation patterns during dry periods in Lithuania. The research covers the period from 1961 to 2010. Atmospheric circulation features were analysed using the Hess and Brezowski classification of macro-circulation ...
Egidijus Rimkus, Justas Kažys, Donatas Valiukas, Gintautas Stankūnavičius   +3 more
doaj  

Stabilising the Lattice Oxygen Oxidation Mechanism Through Iridium Single Atoms in Chromium‐Doped Cobalt Iron Layered Double Hydroxides

Advanced Science, EarlyView.
Iridium single atoms and Cr doping synergistically activate and stabilise the lattice oxygen oxidation mechanism in CoFe layered double hydroxides. Electronic modulation enhances metal–oxygen covalency, suppresses over‐oxidation, and enables durable oxygen evolution, delivering high‐performance anion exchange membrane water electrolysis with ...
Parisa Eskandari, Shujie Zhou, Jodie Yuwono, Yufei Zhao, Hanyu Xu, Zhihong Tian, Jingwen Ba, Ming Zhang, Bernt Johannessen, Thanh Son Bui, Richard F. Webster, Jing Chu, Xunyu Lu, Rose Amal   +13 more
wiley   +1 more source