Results 131 to 140 of about 36,863 (258)

Atmospheric circulation over Europe during the Younger Dryas. [PDF]

open access: yesSci Adv, 2020
Rea BR   +9 more
europepmc   +1 more source

Adaptive and Highly Efficient Thermoregulation Based on Multi‐Dimensional Janus Film

open access: yesAdvanced Science, EarlyView.
A switchable TiO2/MXene/PDMS Janus membrane enables dual‐mode radiative cooling and solar heating, achieving sub‐ambient cooling of 17.89°C and above‐ambient heating of 13.82°C. Adaptive temperature regulation was demonstrated with a low power integrated autonomous smart curtain system, providing a sustainable and energy‐efficient alternative for ...
Yuqing Shi   +6 more
wiley   +1 more source

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

open access: yesAdvanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin   +23 more
wiley   +1 more source

Observed interannual changes beneath Filchner-Ronne Ice Shelf linked to large-scale atmospheric circulation. [PDF]

open access: yesNat Commun, 2021
Hattermann T   +8 more
europepmc   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

open access: yesAdvanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo   +18 more
wiley   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen   +5 more
wiley   +1 more source

Water isotope-temperature relationship variability across Antarctica set by atmospheric circulation. [PDF]

open access: yesNat Geosci
Casado M   +19 more
europepmc   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

open access: yesAdvanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song   +5 more
wiley   +1 more source

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