Results 111 to 120 of about 36,528 (256)

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Titan’s Atmospheric Albedo Asymmetry and Seasonal Variability Observed through the Cassini Imaging Science Subsystem

The Planetary Science Journal
Using images from Cassini, we analyzed the north–south albedo asymmetry that has been observed in the atmosphere of Saturn’s moon, Titan. Suitable images from the Cassini Imaging Science Subsystem taken at 889 nm spanned from 2004 to 2017—around half of ...
C. Snell, D. Banfield
doaj   +1 more source

Robust but weak winter atmospheric circulation response to future Arctic sea ice loss. [PDF]

Nat Commun, 2022
Smith DM, Eade R, Andrews MB, Ayres H, Clark A, Chripko S, Deser C, Dunstone NJ, García-Serrano J, Gastineau G, Graff LS, Hardiman SC, He B, Hermanson L, Jung T, Knight J, Levine X, Magnusdottir G, Manzini E, Matei D, Mori M, Msadek R, Ortega P, Peings Y, Scaife AA, Screen JA, Seabrook M, Semmler T, Sigmond M, Streffing J, Sun L, Walsh A.   +31 more
europepmc   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Emerging Climate Change Signals in Atmospheric Circulation

AGU Advances
The circulation response to climate change shapes regional climate and extremes. Over the last decade an increasing number of atmospheric circulation signals have been documented, with some attributed to human activities.
T. A. Shaw, J. M. Arblaster, T. Birner, A. H. Butler, D. I. V. Domeisen, C. I. Garfinkel, H. Garny, K. M. Grise, A. Yu. Karpechko   +8 more
doaj   +1 more source

Hydroclimatic record from an Altiplano cushion peatland (24°S) indicates large-scale reorganisation of atmospheric circulation for the late Holocene. [PDF]

PLoS One, 2022
Lücke A, Kock S, Wissel H, Kulemeyer JJ, Lupo LC, Schäbitz F, Schittek K.   +6 more
europepmc   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Mechanisms of Superrotation in Slowly Rotating and Tidally Locked Planets

The Planetary Science Journal
Superrotation is a common feature of quickly rotating gas giants (e.g., Jupiter), slowly rotating planetary bodies (e.g., Titan), and tidally locked planets.
Quentin Nicolas, Geoffrey K. Vallis
doaj   +1 more source

Atmospheric Circulation of Exoplanets

, 2009
We survey the basic principles of atmospheric dynamics relevant to explaining existing and future observations of exoplanets, both gas giant and terrestrial. Given the paucity of data on exoplanet atmospheres, our approach is to emphasize fundamental principles and insights gained from Solar-System studies that are likely to be generalizable to ...
Showman, Adam P., Cho, James Y-K., Menou, Kristen   +2 more
openaire   +2 more sources

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source