Results 91 to 100 of about 1,246,781 (254)

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

A novel model to predict the physical state of atmospheric H2SO4/NH3/H2O aerosol particles [PDF]

, 2003
Colberg CA, Luo BP, Wernli H, Koop T, Peter T. A novel model to predict the physical state of atmospheric H2SO4/NH3/H2O aerosol particles. ATMOSPHERIC CHEMISTRY AND PHYSICS.
Wernli, H., Luo, B. P., Koop, Thomas ; https://orcid.org/, Peter, T., Colberg, C. A.   +4 more
core   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

The Atmospheric General Circulation in Thermodynamical Coordinates [PDF]

, 2014
The zonal and meridional components of the atmospheric general circulation are used to define a global thermodynamic streamfunction in dry static energy versus latent heat coordinates.
Zika, Jan D., Laliberté, Frédéric B., Zika, Jan, Kjellsson, Joakim, Döös, Kristofer, Kjellsson, Joakim,, Döös, Kristofer,   +6 more
core   +1 more source

How Global Atmospheric Circulation Indirectly Influences Streamflow Variations in Karst Basin Through Rainfall

Water Resources Research
Global climate change has profoundly influenced atmospheric circulation systems, with frequent heavy rainfall events crucial in determining long‐term hydrological trends.
Benjin Yu, Rui Li, Feiyang Cai, Zhenhong Yi, Chaoyang Xue, Wanquan Zhang   +5 more
doaj   +1 more source

Global reorganization of atmospheric circulation during Dansgaard-Oeschger cycles. [PDF]

Proc Natl Acad Sci U S A, 2023
Fohlmeister J, Sekhon N, Columbu A, Vettoretti G, Weitzel N, Rehfeld K, Veiga-Pires C, Ben-Yami M, Marwan N, Boers N.   +9 more
europepmc   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

Synchronous centennial abrupt events in the ocean and atmosphere during the last deglaciation [PDF]

, 2015
This study was funded by the European Research Council, the Philip Leverhulme Trust, the National Science Foundation and a Marie Curie Reintegration Grant.Antarctic ice-core data reveal that the atmosphere experienced abrupt centennial increases in CO2 ...
Morris, Paul J., Burke, Andrea, Ng, Hong Chin, Southon, John, Robinson, Laura F., Spooner, Peter, Chen, Tianyu   +6 more
core   +1 more source

Metal‐Half‐Salen Chemistry for One‐Pot Mineralization on Hydrophobic Polymer Membranes

Advanced Science, EarlyView.
Here we report a versatile one‐pot synthetic strategy for organic–inorganic composite membranes, which leverages a metal half‐Salen system to precisely govern the competing kinetics of coordination and hydrolysis. In contrast to conventional two‐step metal‐phenol chemistries, our integrated approach substantially simplifies the fabrication process ...
Rou‐Ming Wen, Hao Ye, Ming‐Bang Wu, Lu‐Lin Ma, Qi‐Hui Ye, Zi‐Hao Yuan, Yi Xie, Juming Yao, Hao‐Cheng Yang   +8 more
wiley   +1 more source