Results 101 to 110 of about 1,246,781 (254)

Major Δ14C excursions during the late glacial and early Holocene: changes in ocean ventilation or solar forcing of climate change? [PDF]

, 2003
The atmospheric 14C record during the Late Glacial and the early Holocene shows sharp increases simultaneous with cold climatic phases. These increases in the atmospheric 14C content are usually explained as the effect of reduced oceanic CO2 ventilation ...
Geel, B. van, Renssen, H, van der Plicht, Johannes, van der Plicht, J., Renssen, Hans,, Geel, Bas van,, Plicht, J. van der, Renssen, H., van Geel, B., Plicht, Johannes van der,   +9 more
core   +1 more source

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

Decadal-interdecadal climate variability over Antarctica and linkages to the Tropics : analysis of ice core, instrumental, and tropical proxy data [PDF]

, 2012
The Antarctic continent contains the majority of the global ice volume and plays an important role in a changing climate. The nature and causes of Antarctic climate variability are, however, poorly understood beyond interannual time scales due to the ...
Okumura, Yuko, Schneider, David, Deser, Clara, Wilson, Rob   +3 more
core   +1 more source

Summertime Arctic and North Atlantic–Eurasian circulation regimes under climate change [PDF]

Weather and Climate Dynamics
This study explores the projected response of atmospheric circulation regimes, which are preferred and recurrent large-scale circulation patterns, to future climate change scenarios.
J. M. Müller, O. A. Landgren, D. Handorf   +2 more
doaj   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Extreme temperature fluctuations in laboratory models of the mid-latitude atmospheric circulation. [PDF]

Sci Rep, 2023
Vincze M, Hancock C, Harlander U, Rodda C, Speer K.   +4 more
europepmc   +1 more source

Nanometer Layer Coating to Lactose Particles for Optimization of Dexamethasone Pulmonary Delivery

Advanced Science, EarlyView.
Nanometer layer coating (NLC) was investigated and its mechanism illustrated by advanced characterization techniques. The effects and application for the inhalation of dexamethasone (DEX) were demonstrated through in vitro and in vivo evaluation. This approach increased DEX bioavailability and enabled the dose to be reduced to 1/30 of the intravenous ...
Qin Nie, Jiahe Liu, Xiangyu Zhao, Siying Yang, Han Sun, Bingqian Jia, Xiaohong Ren, Xintao Chen, Lixin Sun, Li Wu, Caifen Wang, Jiwen Zhang   +11 more
wiley   +1 more source

Changes in atmospheric circulation and evapotranspiration are reducing rainfall in the Brazilian Cerrado. [PDF]

Sci Rep, 2023
Hofmann GS, Silva RC, Weber EJ, Barbosa AA, Oliveira LFB, Alves RJV, Hasenack H, Schossler V, Aquino FE, Cardoso MF.   +9 more
europepmc   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Heat extremes in Western Europe increasing faster than simulated due to atmospheric circulation trends. [PDF]

Nat Commun, 2023
Vautard R, Cattiaux J, Happé T, Singh J, Bonnet R, Cassou C, Coumou D, D'Andrea F, Faranda D, Fischer E, Ribes A, Sippel S, Yiou P.   +12 more
europepmc   +1 more source