Results 131 to 140 of about 141,901 (265)

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source

Statistical Geochemical Constraints on Present-day Water Outgassing as a Source of Secondary Atmospheres on the TRAPPIST-1 Exoplanets

The Planetary Science Journal
The TRAPPIST-1 planetary system is observationally favorable for studying if planets orbiting M stars can retain atmospheres and host habitable conditions.
Trent B. Thomas, Victoria S. Meadows, Joshua Krissansen-Totton, Megan T. Gialluca, Nicholas F. Wogan, David C. Catling   +5 more
doaj   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

A High-resolution Near-Ultraviolet Transmission Spectrum of KELT-9b: Mg II and Fe II Escaping from the Hottest Known Giant Planet

The Astronomical Journal
We present high-resolution near-ultraviolet observations from the Hubble Space Telescope’s Space Telescope Imaging Spectrograph (STIS) data for the hottest known gas planet, KELT-9b.
Austin Baldwin, Joshua D. Lothringer, Leonardo A. dos Santos, David K. Sing, Zafar Rustamkulov, Nikolay K. Nikolov, Jeff Valenti, Hannah R. Wakeford   +7 more
doaj   +1 more source

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Selective Confinement by a COF‐Derived Sub‐Nanoporous Interface for High‐Performance CoF2 Thermal Battery Cathodes

Advanced Science, EarlyView.
Dissolution and shuttling of TMF cathodes hinders high‐voltage thermal batteries. A novel selective confinement strategy using a sub‐nanoporous COF‐derived carbon interface (0.54 nm pores) on CoF2 suppresses cathode material shuttling. Size‐selective confinement blocks large dissolved ions (∼0.8 nm) while allowing Li⁺ passage, enhancing thermal battery
Mengfan Xu, Jun Zhang, Lili Zhao, Ying Chu, Furui Luo, Xinping Cao, Shengnan Guo, Xueying Wang, Yongping Zhu, Song Wang   +9 more
wiley   +1 more source

Blowin’ in the Nonisothermal Wind: Core-powered Mass Loss with Hydrodynamic Radiative Transfer

The Astrophysical Journal
The mass loss rates of planets undergoing core-powered escape are usually modeled using an isothermal Parker-type wind at the equilibrium temperature, T _eq .
William Misener, Matthäus Schulik, Hilke E. Schlichting, James E. Owen   +3 more
doaj   +1 more source

Single‐Crystal PZT‐Driven Organic Piezo‐Phototronic Adaptive Transistors Toward Advanced Spatiotemporal Visual Computing

Advanced Science, EarlyView.
Here, we propose a single‐crystal PZT‐based piezo‐phototronic organic adaptive memory transistor (OAMT), achieving a record memory window capacity factor (γ) of 0.87 at a low SS of 200 mV/decade via efficient multi‐field control. The device achieves a high recognition accuracy ∼ 90% in neuromorphic simulations, demonstrates robust fault tolerance under
Chenhao Xu, Xingyu Cao, Zewen Li, Shifu Xiong, Yongxu Hu, Zhongwu Wang, Yujie Yuan, Lei Zheng, Wenping Hu   +8 more
wiley   +1 more source

An Empirical Predictive Model for Atmospheric H Lyman‐α Emission Brightness at Mars

Earth and Space Science
Characterizing the abundance of atmospheric hydrogen (H) at Mars is critical for determining the current and, subsequently, the primordial water content on the planet.
Majd Mayyasi, Adil Mayyasi
doaj   +1 more source

ATMOSPHERIC ESCAPE OF CLOSE-IN NEPTUNES [PDF]

Proceedings of the 48-th International student's conferences "Physics of Space", 2020
E. S. Kalinicheva, V. I. Shematovich, Ya. N. Pavlyuchenkov   +2 more
openaire   +1 more source