Results 31 to 40 of about 519,289 (290)

The VLT-FLAMES Tarantula Survey XIX. B-type Supergiants - Atmospheric parameters and nitrogen abundances to investigate the role of binarity and the width of the main sequence [PDF]

, 2015
TLUSTY non-LTE model atmosphere calculations have been used to determine atmospheric parameters and nitrogen (N) abundances for 34 single and 18 binary B-type supergiants (BSGs).
Apellániz, J. Maíz, Crowther, P. A., de Koter, A., de Mink, S. E., Dufton, P. L., Dunstall, P. R., Evans, C. J., Herrero, A., Hénault-Brunet, V., Kalari, V. M., Langer, N., Lennon, D. J., Markova, N., McEvoy, C. M., Najarro, F., Puls, J., Sana, H., Schneider, F. R. N., Simón-Díaz, S., Taylor, W. D., Vink, J. S., Walborn, N. R.   +21 more
core   +3 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Sub-Neptune Memories. I. Implications of Inefficient Mantle Cooling and Silicate Rain

The Astrophysical Journal
We explore the evolution of sub-Neptune (radii between ∼1.5 and 4 R _⊕ ) exoplanet interior structures using our upgraded evolution code, APPLE , which self-consistently couples the thermal and compositional evolution of the whole structure.
Roberto Tejada Arevalo, Akash Gupta, Adam Burrows, Donghao Zheng, Yao Tang, Jie Deng   +5 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Characterization of a boreal convective boundary layer and its impact on atmospheric chemistry during HUMPPA-COPEC-2010 [PDF]

Atmospheric Chemistry and Physics, 2012
We studied the atmospheric boundary layer (ABL) dynamics and the impact on atmospheric chemistry during the HUMPPA-COPEC-2010 campaign. We used vertical profiles of potential temperature and specific moisture, obtained from 132 radio soundings, to ...
H. G. Ouwersloot, J. Vilà-Guerau de Arellano, A. C. Nölscher, M. C. Krol, L. N. Ganzeveld, C. Breitenberger, I. Mammarella, J. Williams, J. Lelieveld   +8 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Fleeting but Not Forgotten: The Imprint of Escaping Hydrogen Atmospheres on Super-Earth Interiors

The Astrophysical Journal
Small, close-in exoplanets are divided into two subpopulations: super-Earths and sub-Neptunes. Most super-Earths are thought to have lost their primordially accreted hydrogen-dominated atmospheres via thermally driven winds.
James G. Rogers, Hilke E. Schlichting, Edward D. Young   +2 more
doaj   +1 more source

Ragweed and sagebrush pollen can distinguish between vegetation types at broad spatial scales

Ecosphere, 2020
Patterns of vegetation distribution at regional to subcontinental scales can inform understanding of climate. Delineating ecoregion boundaries over geologic time is complicated by the difficulty of distinguishing between prairie types at broad spatial ...
Hannah M. Carroll, Alan D. Wanamaker, Lynn G. Clark, Brian J. Wilsey   +3 more
doaj   +1 more source