Results 41 to 50 of about 519,289 (290)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The Astronomical JournalTOI-836 is a ∼2–3 Gyr K dwarf with an inner super Earth ( R = 1.7 R _⊕ , P = 3.8 days) and an outer mini-Neptune ( R = 2.6 R _⊕ , P = 8.6 days). JWST/NIRSpec 2.8–5.2 μ m transmission spectra are flat for both planets.
Michael Zhang +15 more
doaj +1 more source
Atmospheric methane evolution the last 40 years [PDF]
Atmospheric Chemistry and Physics, 2016 Observations at surface sites show an increase in global mean surface methane (CH4) of about 180 parts per billion (ppb) (above 10 %) over the period 1984–2012. Over this period there are large fluctuations in the annual growth rate.
S. B. Dalsøren +8 more
doaj +1 more source
Frontiers in Marine Science, 2022 This document describes best practices for analysis of dissolved organic matter (dissolved organic carbon and total dissolved nitrogen) in seawater samples.
Elisa Halewood +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
The Astronomical JournalThe Kepler mission enabled us to look at the intrinsic population of exoplanets within our galaxy. In period-radius space, the distribution of the intrinsic population of planets contains structure that can trace planet formation and evolution history ...
Anne Dattilo, Natalie M. Batalha
doaj +1 more source
Highly fractionated chromium isotopes in Mesoproterozoic-aged shales and atmospheric oxygen
Nature Communications, 2018 There is a long standing debate whether low atmospheric oxygen levels during the Mesoproterozoic Era hindered the evolution of crown-group animals. Here, the authors show with shale-hosted chromium isotopes that sufficient atmospheric oxygen for crown ...
Donald E. Canfield +7 more
doaj +1 more source
Stellar Parameters of Main Sequence Turn-off Star Candidates Observed with the LAMOST and Kepler
, 2017 Main sequence turn-off (MSTO) stars have advantages as indicators of Galactic evolution since their ages could be robustly estimated from atmospheric parameters.
Bi, Shaolan +12 more
core +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source