Results 61 to 70 of about 3,737,177 (309)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Constraining Atmospheric Composition from the Outflow: Helium Observations Reveal the Fundamental Properties of Two Planets Straddling the Radius Gap

The Astronomical Journal
TOI-836 is a ∼2–3 Gyr K dwarf with an inner super Earth ( R  = 1.7 R _⊕ , P = 3.8 days) and an outer mini-Neptune ( R  = 2.6 R _⊕ , P = 8.6 days). JWST/NIRSpec 2.8–5.2 μ m transmission spectra are flat for both planets.
Michael Zhang, Jacob L. Bean, David Wilson, Girish Duvvuri, Christian Schneider, Heather A. Knutson, Fei Dai, Karen A. Collins, Cristilyn N. Watkins, Richard P. Schwarz, Khalid Barkaoui, Avi Shporer, Keith Horne, Ramotholo Sefako, Felipe Murgas, Enric Palle   +15 more
doaj   +1 more source

Characterization of a boreal convective boundary layer and its impact on atmospheric chemistry during HUMPPA-COPEC-2010 [PDF]

Atmospheric Chemistry and Physics, 2012
We studied the atmospheric boundary layer (ABL) dynamics and the impact on atmospheric chemistry during the HUMPPA-COPEC-2010 campaign. We used vertical profiles of potential temperature and specific moisture, obtained from 132 radio soundings, to ...
H. G. Ouwersloot, J. Vilà-Guerau de Arellano, A. C. Nölscher, M. C. Krol, L. N. Ganzeveld, C. Breitenberger, I. Mammarella, J. Williams, J. Lelieveld   +8 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Ragweed and sagebrush pollen can distinguish between vegetation types at broad spatial scales

Ecosphere, 2020
Patterns of vegetation distribution at regional to subcontinental scales can inform understanding of climate. Delineating ecoregion boundaries over geologic time is complicated by the difficulty of distinguishing between prairie types at broad spatial ...
Hannah M. Carroll, Alan D. Wanamaker, Lynn G. Clark, Brian J. Wilsey   +3 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

A Unified Treatment of Kepler Occurrence to Trace Planet Evolution. II. The Radius Cliff Formed by Atmospheric Escape

The Astronomical Journal
The Kepler mission enabled us to look at the intrinsic population of exoplanets within our galaxy. In period-radius space, the distribution of the intrinsic population of planets contains structure that can trace planet formation and evolution history ...
Anne Dattilo, Natalie M. Batalha
doaj   +1 more source

Atmospheric methane evolution the last 40 years [PDF]

Atmospheric Chemistry and Physics, 2016
Observations at surface sites show an increase in global mean surface methane (CH4) of about 180 parts per billion (ppb) (above 10 %) over the period 1984–2012. Over this period there are large fluctuations in the annual growth rate.
S. B. Dalsøren, C. L. Myhre, G. Myhre, A. J. Gomez-Pelaez, O. A. Søvde, I. S. A. Isaksen, I. S. A. Isaksen, R. F. Weiss, C. M. Harth   +8 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

One-dimensional Microphysics Model of Venusian Clouds from 40 to 100 km: Impact of the Middle-atmosphere Eddy Transport and SOIR Temperature Profile on the Cloud Structure

The Planetary Science Journal
We conducted a simulation of H _2 SO _4 vapor, H _2 O vapor, and H _2 SO _4 –H _2 O liquid aerosols from 40 to 100 km, using a 1D Venus cloud microphysics model based on the one detailed in Imamura & Hashimoto.
Hiroki Karyu, Takeshi Kuroda, Takeshi Imamura, Naoki Terada, Ann Carine Vandaele, Arnaud Mahieux, Sébastien Viscardy   +6 more
doaj   +1 more source