Results 61 to 70 of about 519,289 (290)

Thermally Driven Atmospheric Escape: Transition from Diffusion-limited to Drag-off Escape

The Planetary Science Journal
We examine the transition from diffusion-limited to drag-off escape using a direct simulation Monte Carlo (DSMC) model developed to simulate planetary atmospheres, referred to as Harrah.
Jack C. Evans, Shane Robert Carberry Mogan, Robert E. Johnson, Orenthal J. Tucker   +3 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

A persistently low level of atmospheric oxygen in Earth’s middle age

Nature Communications, 2021
Constraining the rise in atmospheric oxygen through the early Earth is important to understand the evolution of complex life. Here, the authors find that a major rise in atmospheric oxygen level occurred after the Great Oxidation Event, followed by pO2 ...
Xiao-Ming Liu, Linda C. Kah, Andrew H. Knoll, Huan Cui, Chao Wang, Andrey Bekker, Robert M. Hazen   +6 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A Metal-poor Atmosphere with a Hot Interior for a Young Sub-Neptune Progenitor: JWST/NIRSpec Transmission Spectrum of V1298 Tau b

The Astronomical Journal
We present the JWST/NIRSpec G395H transmission spectrum of the young (10–30 Myr) transiting planet V1298 Tau b (9.85 ± 0.35 R _⊕ , T _eq  = 670 K). Combined Hubble Space Telescope and JWST observations reveal a haze-free, H/He-dominated atmosphere with a
Saugata Barat, Jean-Michel Désert, Sagnick Mukherjee, Jayesh M. Goyal, Qiao Xue, Yui Kawashima, Allona Vazan, William Misener, Hilke E. Schlichting, Jonathan J. Fortney, Jacob L. Bean, Swaroop Avarsekar, Gregory W. Henry, Robin Baeyens, Michael R. Line, John H. Livingston, Trevor David, Erik A. Petigura, James T. Sikora, Hinna Shivkumar, Adina D. Feinstein, Antonija Oklopčić   +21 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Aquatic ecosystems as a final receptor of atmospheric organic particulate-bound pollutants: a plea for the integration of aquatic ecotoxicology into the risk assessment of air pollution

Environmental Sciences Europe
Background Air pollution has detrimental effects on human health and is estimated to cause millions of premature deaths worldwide each year. The effects of polluted air on human health, ranging from respiratory and cardiovascular disorders to cognitive ...
Marc Wollenweber, Markus Schmitz, Saeed S. Albaseer, Sabrina Schiwy, Natalie Reininger, Werner Brack, Jörg Oehlmann, Joachim Curtius, Alexander L. Vogel, Henner Hollert   +9 more
doaj   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Understanding B-type Supergiants in the Low Metallicity Environment of the SMC

, 2003
Spectroscopic analyses of 7 SMC B-type supergiants and 1 giant have been undertaken using high resolution optical data obtained on the VLT with UVES. FASTWIND, a non-LTE, spherical,line-blanketed model atmosphere code was used to derive atmospheric and ...
Abbott, Azzopardi, Becker, Becker, Becker, Bresolin, Bresolin, Bresolin, C. Trundle, Castor, Crowther, D. J. Lennon, de Mello, Denissenkov, Dufton, Eber, Eggenberger, Fitzpatrick, Fitzpatrick, Garmany, Gies, Hamann, Harries, Haser, Haser, Heger, Herrero, Herrero, Hillier, Hillier, Howarth, Howarth, Hubeny, J. Puls, Kamp, Kilian, Kudritzki, Kudritzki, Kudritzki, Kudritzki, Kudritzki, Kudritzki, Kurt, Lamers, Lamers, Langer, Leitherer, Leitherer, Lennon, Lennon, Lennon, Lennon, Lennon, Maeder, Maeder, Martins, Massa, Massey, Matthews, McErlean, McErlean, Mihalas, Monteverde, Monteverde, Monteverde, Monteverde, Osmer, Osmer, P. L. Dufton, Pauldrach, Pettini, Prinja, Przybylski, Przybylski, Puls, Puls, Rolleston, Rucinski, Ryans, Sanduleak, Santolaya-Rey, Schaller, Smartt, Talon, Trundle, Urbaneja, Venn, Venn, Venn, Venn, Venn, Vink, Voels, Vrancken, Walborn, Walborn, Wellstein, Wolf, Wolf   +98 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source