Results 51 to 60 of about 3,737,177 (309)

Toward a Cenozoic history of atmospheric CO2

Science, 2023
The geological record encodes the relationship between climate and atmospheric carbon dioxide (CO2) over long and short timescales, as well as potential drivers of evolutionary transitions.
Bärbel Hönisch, Dana L Royer, D. Breecker, P. Polissar, Gabriel J Bowen, M. Henehan, Ying Cui, M. Steinthorsdottir, Jennifer C McElwain, M. J. Kohn, A. Pearson, S. Phelps, K. Uno, A. Ridgwell, E. Anagnostou, J. Austermann, M. Badger, R. Barclay, P. Bijl, T. Chalk, C. Scotese, E. de la Vega, R. DeConto, K. Dyez, V. Ferrini, Peter J Franks, C. Giulivi, M. Gutjahr, D. Harper, Laura L. Haynes, M. Huber, K. Snell, B. Keisling, Wilfried Konrad, T. Lowenstein, A. Malinverno, M. Guillermic, Luz María Mejía, Joseph N. Milligan, J. Morton, L. Nordt, R. Whiteford, A. Roth-Nebelsick, J. Rugenstein, Morgan F. Schaller, N. Sheldon, S. Sosdian, E. Wilkes, C. Witkowski, Yi Ge Zhang, Lloyd B. Anderson, D. Beerling, C. Bolton, T. Cerling, J. Cotton, J. Da, D. Ekart, G. L. Foster, David R. Greenwood, E. Hyland, E. Jagniecki, J. Jasper, J. Kowalczyk, L. Kunzmann, W. Kürschner, C. W. Lawrence, C. Lear, M. A. Martínez-Botí, Daniel P. Maxbauer, P. Montagna, B. Naafs, J. Rae, M. Raitzsch, G. Retallack, Simon J. Ring, Osamu Seki, Julio Sepúlveda, A. Sinha, Tekie F. Tesfamichael, A. Tripati, J. van der Burgh, Jimin Yu, J. Zachos, Laiming Zhang   +83 more
semanticscholar   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Sub-Neptune Memories. I. Implications of Inefficient Mantle Cooling and Silicate Rain

The Astrophysical Journal
We explore the evolution of sub-Neptune (radii between ∼1.5 and 4 R _⊕ ) exoplanet interior structures using our upgraded evolution code, APPLE , which self-consistently couples the thermal and compositional evolution of the whole structure.
Roberto Tejada Arevalo, Akash Gupta, Adam Burrows, Donghao Zheng, Yao Tang, Jie Deng   +5 more
doaj   +1 more source

Deuterium Escape on Photoevaporating Sub-Neptunes

The Astrophysical Journal Letters, 2023
We investigate the evolution of the deuterium-to-hydrogen (D/H) mass ratio driven by EUV photoevaporation of hydrogen-rich atmospheres of close-in sub-Neptunes around solar-type stars.
Pin-Gao Gu, Howard Chen
doaj   +1 more source

Constraining the early evolution of Venus and Earth through atmospheric Ar, Ne isotope and bulk K/U ratios

, 2020
The atmospheric noble gas isotope and elemental bulk ratios on Venus and Earth provide important information on their origin and evolution. If the protoplanets grew to a certain mass (i.e.
H. Lammer, M. Leitzinger, M. Scherf, P. Odert, C. Burger, D. Kubyshkina, C. Johnstone, T. Maindl, C. Schäfer, M. Güdel, N. Tosi, A. Nikolaou, E. Marcq, N. Erkaev, L. Noack, K. Kislyakova, L. Fossati, E. Pilat-Lohinger, F. Ragossnig, E. Dorfi   +19 more
semanticscholar   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Fleeting but Not Forgotten: The Imprint of Escaping Hydrogen Atmospheres on Super-Earth Interiors

The Astrophysical Journal
Small, close-in exoplanets are divided into two subpopulations: super-Earths and sub-Neptunes. Most super-Earths are thought to have lost their primordially accreted hydrogen-dominated atmospheres via thermally driven winds.
James G. Rogers, Hilke E. Schlichting, Edward D. Young   +2 more
doaj   +1 more source