Results 81 to 90 of about 2,615,185 (246)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Charge Structure and Lightning Discharge in a Thunderstorm Over the Central Tibetan Plateau

Geophysical Research Letters
The evolution of charge structure involved in lightning discharge of a thunderstorm over the central Tibetan Plateau is investigated for the first time, based on the data from very high frequency interferometer, radar and sounding.
Dongxia Liu, Fengquan Li, Xiushu Qie, Zhuling Sun, Yu Wang, Shanfeng Yuan, Chunfa Sun, Kexin Zhu, Lei Wei, Huimin Lyu, Rubin Jiang   +10 more
doaj   +1 more source

A multi-location joint field observation of the stratosphere and troposphere over the Tibetan Plateau

Earth and Planetary Physics, 2019
The unique geographical location and high altitude of the Tibetan Plateau can greatly influence regional weather and climate. In particular, the Asian summer monsoon (ASM) anticyclone circulation system over the Tibetan Plateau is recognized to be a ...
JinQiang Zhang, Yi Liu, HongBin Chen, ZhaoNan Cai, ZhiXuan Bai, LingKun Ran, Tao Luo, Jing Yang, YiNan Wang, YueJian Xuan, YinBo Huang, XiaoQing Wu, JianChun Bian, DaRen Lu   +13 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Do atmospheric aerosols form glasses? [PDF]

, 2008
Zobrist B, Marcolli C, Pedernera DA, Koop T. Do atmospheric aerosols form glasses? ATMOSPHERIC CHEMISTRY AND PHYSICS. 2008;8(17):5221-5244.A new process is presented by which water soluble organics might influence ice nucleation, ice growth, chemical ...
Koop, Thomas, B. Zobrist, D. A. Pedernera, Koop, T., Koop, Thomas ; https://orcid.org/, Pedernera, D. A., Marcolli, C., C. Marcolli, T. Koop, Marcolli, Claudia, Pedernera, D.A., Zobrist, Bernhard, Zobrist, B.   +12 more
core   +2 more sources

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

A Novel Method for Estimating the Vertical Velocity of Air with a Descending Radiosonde System

Remote Sensing, 2019
Knowledge of vertical air motion in the atmosphere is important for both meteorological and climate studies due to its impact on clouds, precipitation and the vertical transport of air masses, heat, momentum, and composition.
Jinqiang Zhang, Hongbin Chen, Yanliang Zhu, Hongrong Shi, Youtong Zheng, Xiangao Xia, Yupeng Teng, Fei Wang, Xinlei Han, Jun Li, Yuejian Xuan   +10 more
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

An Observational and Model Characterization of Vertical Structure of Wind Fields over Eastern United States: A Case Study of Sterling, Virginia

Advances in Meteorology, 2016
The performance of twenty GCMs that participated in the Coupled Model Intercomparison Phase 5 (CMIP5) is evaluated at Sterling, Virginia, by comparing model outputs with radiosonde observational dataset and reanalysis dataset.
Sium Gebremariam, Belay Demoz, Churchill Okonkwo, Ricardo K. Sakai   +3 more
doaj   +1 more source