Results 61 to 70 of about 84,293 (267)
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
Upward negative leaders in positive triggered lightning: Stepping and branching in the initial stage
Geophysical Research Letters, 2017 By conducting comprehensive observation on the rarely triggered positive lightning flashes, two cases of upward negative leaders were quantitatively investigated with simultaneous data of current, optical, and electromagnetic field changes at fine time ...
Yunjiao Pu +6 more
doaj +1 more source
Observation of “Topological” Microflares in the Solar Atmosphere [PDF]
Research Notes of the AAS, 2017 We report on observation of the unusual kind of solar microflares, presumably associated with the so-called "topological trigger" of magnetic reconnection, which was theoretically suggested long time ago by Gorbachev et al. (Sov. Ast. 1988, v.32, p.308) but has not been clearly identified so far by observations. As can be seen in pictures by Hinode SOT
Yurii V. Dumin, Boris V. Somov
openaire +3 more sources
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Effect of terahertz irradiation on DNA damage repair in living cells
FEBS Open Bio, EarlyView.We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno +3 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Gaoyuan qixiangUsing observation data from 945 ground-based Global Navigation Satellite System （GNSS） stations in the summer of 2023 in China， the double-difference （DD） network algorithm and Precise Point Positioning （PPP） algorithm were used to invert the ...
Jin LUO +6 more
doaj +1 more source
Dust Properties and Radiative Impacts at a Suburban Site during 2004–2017 in the North China Plain
Remote Sensing, 2019 Aerosols and their radiative effects are of primary interest in climate research because of their vital influence on climate change. Dust aerosols are an important aerosol type in the North China Plain (NCP), mainly as a result of long-range transport ...
Jinqiang Zhang +5 more
doaj +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source