Results 61 to 70 of about 2,513,508 (291)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
iScienceSummary: This study investigates atmospheric aerosol trends and their climatic impacts across Africa from 1980 to 2024 using MERRA-2 reanalysis data.
Daniel O. Omokpariola
doaj +1 more source
Observations of Exoplanet Atmospheres [PDF]
Publications of the Astronomical Society of the Pacific, 2015 Detailed characterization of an extrasolar planet's atmosphere provides the best hope for distinguishing the makeup of its outer layers, and the only hope for understanding the interplay between initial composition, chemistry, dynamics & circulation, and disequilibrium processes.
openaire +3 more sources
Observable medium effects for atmospheric neutrinos [PDF]
Proceedings of International Europhysics Conference on High Energy Physics — PoS(hep2001), 2001 We discuss the possibility to observe matter effects in atmospheric neutrino oscillations. The main conclusion is that an impact on the nu_mu survival probability requires the action of the MSW resonance, which becomes visible for baselines above ~7000 km. The associated muon charge asymmetry carries information on theta_{13} and the sign of Dm^2_{31}.
Bernabeu, J., Palomares-Ruiz, S.
openaire +2 more sources
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Advances in Meteorology, 2014 The interannual variability of West African jet streams and their association with rainfall are reexamined using European Reanalysis ERA-Interim 1979–2011.
Churchill Okonkwo +2 more
doaj +1 more source
Comparison of the Performance of Different Lightning Jump Algorithms in Beijing
应用气象学报, 2021 Based on S-band Doppler weather radar raw data, the total lightning location data of Beijing Lightning Network (BLNET) and hailfall reports from Beijing Meteorological Service, two lightning jump algorithms, Gatlin algorithm and σ algorithm, with ...
Tian Ye +7 more
doaj +1 more source
Observing the Tropical Atmosphere in Moisture Space [PDF]
Journal of the Atmospheric Sciences, 2018 Measurements from the Barbados Cloud Observatory are analyzed to identify the processes influencing the distribution of moist static energy and the large-scale organization of tropical convection. Five years of water vapor and cloud profiles from a Raman lidar and cloud radar are composed to construct the structure of the observed atmosphere in ...
Schulz, H. +1 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source