Results 51 to 60 of about 2,513,508 (291)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Water Vapor Characteristics of Extreme Precipitation in Yingjiang, the “Rain Pole” of Mainland China

Applied Sciences
In the Yingjiang area of western Yunnan, precipitation is high throughout the year, making it one of the regions with the highest annual precipitation in mainland China.
Jin Luo, Liyan Xie, Weimin Wang, Yunchang Cao, Hong Liang, Yizhu Wang, Balin Xu   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

University of Arizona, Institute of Atmospheric Physics, Progress Report No. 3

, 1956
This title from the Institute of Atmospheric Physics Reports collection is made available by the Department of Hydrology & Atmospheric Sciences and the University Libraries, University of Arizona.
Braham, Roscoe R., Jr.
core   +4 more sources

Development of Side Bidirectional Leader and Its Effect on Channel Branching of the Progressing Positive Leader of Lightning

Geophysical Research Letters, 2019
Fine time‐resolved images of the development of lightning bidirectional leaders below the cloud base were captured by a high‐speed camera in association with multiband electromagnetic field measurements.
Shanfeng Yuan, Rubin Jiang, Xiushu Qie, Zhuling Sun, Dongfang Wang, Abhay Srivastava   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Can terrestrial laser scanners (TLSs) and hemispherical photographs predict tropical dry forest succession with liana abundance? [PDF]

Biogeosciences, 2017
Tropical dry forests (TDFs) are ecosystems with long drought periods, a mean temperature of 25 °C, a mean annual precipitation that ranges from 900 to 2000 mm, and that possess a high abundance of deciduous species (trees and lianas). What remains of the
G. A. Sánchez-Azofeifa, J. A. Guzmán-Quesada, M. Vega-Araya, C. Campos-Vargas, S. M. Durán, N. D'Souza, T. Gianoli, C. Portillo-Quintero, I. Sharp   +8 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Evaluation of the CRTM Land Emissivity Model over Grass and Sand Surfaces Using Ground-Based Measurements

Remote Sensing, 2023
Microwave surface emissivity is complex and variable, leading to increased difficulty in accurately retrieving atmospheric parameters and assimilating satellite microwave observations over land.
Yidan Wang, Wenying He, Minzheng Duan, Hailei Liu, Hongbin Chen, Congzhen Han, Weidong Nan   +6 more
doaj   +1 more source