Results 41 to 50 of about 84,293 (267)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Can terrestrial laser scanners (TLSs) and hemispherical photographs predict tropical dry forest succession with liana abundance? [PDF]

Biogeosciences, 2017
Tropical dry forests (TDFs) are ecosystems with long drought periods, a mean temperature of 25 °C, a mean annual precipitation that ranges from 900 to 2000 mm, and that possess a high abundance of deciduous species (trees and lianas). What remains of the
G. A. Sánchez-Azofeifa, J. A. Guzmán-Quesada, M. Vega-Araya, C. Campos-Vargas, S. M. Durán, N. D'Souza, T. Gianoli, C. Portillo-Quintero, I. Sharp   +8 more
doaj   +1 more source

Evaluation of the CRTM Land Emissivity Model over Grass and Sand Surfaces Using Ground-Based Measurements

Remote Sensing, 2023
Microwave surface emissivity is complex and variable, leading to increased difficulty in accurately retrieving atmospheric parameters and assimilating satellite microwave observations over land.
Yidan Wang, Wenying He, Minzheng Duan, Hailei Liu, Hongbin Chen, Congzhen Han, Weidong Nan   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Spatiotemporal analysis of atmospheric aerosols in African environments using MERRA-2 data (1980–2024): Impacts on climate extremes

iScience
Summary: This study investigates atmospheric aerosol trends and their climatic impacts across Africa from 1980 to 2024 using MERRA-2 reanalysis data.
Daniel O. Omokpariola
doaj   +1 more source

The increasing atmospheric CO2 over India: Comparison to global trends

iScience, 2022
Summary: Atmospheric CO2 is the key Greenhouse Gas in terms of its global warming potential and anthropogenic sources. Therefore, it is important to analyze the changes in the concentration of atmospheric CO2 to monitor regional and global climate change.
Jayanarayanan Kuttippurath, Rony Peter, Ajay Singh, Sarath Raj   +3 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Channel branching and zigzagging in negative cloud-to-ground lightning

Scientific Reports, 2017
A fundamental question in lightning flash concerns why the discharge channel propagates in a zig-zag manner and produces extensive branches. Here we report the optical observation of two negative cloud-to-ground lightning discharges with very high ...
Rubin Jiang, Xiushu Qie, Hongbo Zhang, Mingyuan Liu, Zhuling Sun, Gaopeng Lu, Zhichao Wang, Yu Wang   +7 more
doaj   +1 more source