Results 41 to 50 of about 2,615,185 (246)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evaluation of the CRTM Land Emissivity Model over Grass and Sand Surfaces Using Ground-Based Measurements

Remote Sensing, 2023
Microwave surface emissivity is complex and variable, leading to increased difficulty in accurately retrieving atmospheric parameters and assimilating satellite microwave observations over land.
Yidan Wang, Wenying He, Minzheng Duan, Hailei Liu, Hongbin Chen, Congzhen Han, Weidong Nan   +6 more
doaj   +1 more source

Semi-Contained Interactions of Atmospheric Neutrinos in the MACRO Detector [PDF]

, 2002
Atmospheric neutrinos arise from the decay of particles (primarily pions, muons and kaons) produced in the collision of high energy cosmic ray particles with the atmosphere.
Nolty, R, Nolty, Robert G.
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Spatiotemporal analysis of atmospheric aerosols in African environments using MERRA-2 data (1980–2024): Impacts on climate extremes

iScience
Summary: This study investigates atmospheric aerosol trends and their climatic impacts across Africa from 1980 to 2024 using MERRA-2 reanalysis data.
Daniel O. Omokpariola
doaj   +1 more source

Can terrestrial laser scanners (TLSs) and hemispherical photographs predict tropical dry forest succession with liana abundance? [PDF]

Biogeosciences, 2017
Tropical dry forests (TDFs) are ecosystems with long drought periods, a mean temperature of 25 °C, a mean annual precipitation that ranges from 900 to 2000 mm, and that possess a high abundance of deciduous species (trees and lianas). What remains of the
G. A. Sánchez-Azofeifa, J. A. Guzmán-Quesada, M. Vega-Araya, C. Campos-Vargas, S. M. Durán, N. D'Souza, T. Gianoli, C. Portillo-Quintero, I. Sharp   +8 more
doaj   +1 more source

The increasing atmospheric CO2 over India: Comparison to global trends

iScience, 2022
Summary: Atmospheric CO2 is the key Greenhouse Gas in terms of its global warming potential and anthropogenic sources. Therefore, it is important to analyze the changes in the concentration of atmospheric CO2 to monitor regional and global climate change.
Jayanarayanan Kuttippurath, Rony Peter, Ajay Singh, Sarath Raj   +3 more
doaj   +1 more source

CHARM-F: The Airborne Integral Path Differential Absorption Lidar for Simultaneous Measurements of Atmospheric CO2 and CH4 [PDF]

, 2010
CHARM-F (CO2 and CH4 Atmospheric Remote Monitoring – Flugzeug) is DLR’s airborne Integral Path Differential Absorption lidar for simultaneous measurements of the column weighted-average dry-air mixing ratios of atmospheric carbon dioxide and methane ...
Schweyer, Sebastian, Meissner, Ansgar, Kiemle, Christoph, Fix, Andreas, Löhring, Jens, Büdenbender, Christian, Quatrevalet, Mathieu, Hoffmann, Dieter, Amediek, Axel, Luttmann, Jörg, Ehret, Gerhard, Wirth, Martin   +11 more
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source