Results 31 to 40 of about 987,964 (347)

A Time-Gated, Time-Correlated Single-Photon-Counting Lidar to Observe Atmospheric Clouds at Submeter Resolution

Remote Sensing, 2023
Most lidars used for cloud observations have the range resolution of about 10 m, so they are incapable of resolving submeter-scale processes that are crucial to cloud evolution.
Fan Yang, Yong Meng Sua, Alexandros Louridas, Katia Lamer, Zeen Zhu, Edward Luke, Yu-Ping Huang, Pavlos Kollias, Andrew M. Vogelmann, Allison McComiskey   +9 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Surface Chlorophyll-a Concentration Spatio-Temporal Variations in the Northern South China Sea Detected Using MODIS Data

Terrestrial, Atmospheric and Oceanic Sciences, 2015
This study examines the spatio-temporal variations in the sea-surface chlorophyll-a (Chl-a) concentration and their associated underlying driving forces in the northern South China Sea (SCS) from 2004 - 2010. A stratified analysis method and the Moderate
Meihong Fang, Weimin Ju, Xiangnan Liu, Zhifeng Yu, and Feng Qiu   +4 more
doaj   +1 more source

EUV Irradiance Inputs to Thermospheric Density Models: Open Issues and Path Forward

, 2018
One of the objectives of the NASA LWS Institute on Nowcasting of Atmospheric Drag for LEO Spacecraft was to investigate whether and how to increase the accuracy of atmospheric drag models by improving the quality of the solar forcing inputs, namely ...
Bruinsma, S., Vourlidas, A.
core   +1 more source

Astrometric calibration and performance of the Dark Energy Camera [PDF]

, 2017
We characterize the ability of the Dark Energy Camera (DECam) to perform relative astrometry across its 500~Mpix, 3 deg^2 science field of view, and across 4 years of operation.
A. A. Plazas, A. Benoit-Lévy, A. Carnero Rosell, A. R. Walker, A. Roodman, C. E. Cunha, D. Brooks, D. Gruen, D. J. James, D. L. Burke, D. L. DePoy, D. W. Gerdes, E. Fernandez, E. Krause, E. S. Rykoff, E. Sanchez, E. Suchyta, F. Menanteau, F. Sobreira, G. Gutierrez, G. M. Bernstein, G. Tarle, H. T. Diehl, I. Sevilla-Noarbe, J. Carretero, J. Frieman, J. García-Bellido, J. Gschwend, J. L. Marshall, K. Bechtol, K. Honscheid, K. Kuehn, K. Reil, L. N. da Costa, M. A. G. Maia, M. Carrasco Kind, M. E. C. Swanson, M. March, M. Schubnell, M. Smith, M. Soares-Santos, N. Kuropatkin, null null, P. Fosalba, R. A. Gruendl, R. Armstrong, R. C. Smith, R. L. C. Ogando, R. Miquel, R. Schindler, S. Allam, S. Desai, S. Kent, T. F. Eifler, T. M. C. Abbott, T. S. Li, V. Scarpine   +56 more
core   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Geochemical and Geophysical Characteristics of the Balud Ophiolitic Complex (BOC), Masbate Island, Philippines: Implications for its Generation, Evolution and Emplacement

Terrestrial, Atmospheric and Oceanic Sciences, 2015
This paper presents the first field, geochemical and geophysical information on the recently recognized Early Cretaceous Balud Ophiolitic Complex (BOC) in the island of Masbate in the Central Philippines.
Pearlyn C. Manalo, Carla B. Dimalanta, Decibel V. Faustino-Eslava, Betchaida D. Payot, Noelynna T. Ramos, Karlo L. Queaño, Americus D. C. Perez, and Graciano P. Yumul Jr.   +7 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Lorenz Energy Cycle: Another Way to Understand the Atmospheric Circulation on Tidally Locked Terrestrial Planets

The Planetary Science Journal, 2023
In this study, we employ and modify the Lorenz energy cycle (LEC) framework as another way to understand the atmospheric circulation on tidally locked terrestrial planets. It well describes the atmospheric general circulation in the perspective of energy
Shuang Wang, Jun Yang
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source