Results 31 to 40 of about 223,618 (266)

Continuous measurements of atmospheric oxygen and carbon dioxide on a North Sea gas platform [PDF]

, 2010
A new atmospheric measurement station has been established on the North Sea oil and gas production platform F3, 200 km north off the Dutch coast (54°51' N, 4°44' E).
Neubert, R.E.M.,, S. van der Laan, Meijer, H. A. J., R. E. M. Neubert, Laan-Luijkx, I.T., van der, Laan, S., van der, Laan-Luijkx, I.T. van der, Laan, S. van der, van der Laan, S., I. T. van der Laan-Luijkx, H. A. J. Meijer, van der Laan-Luijkx, I.T., Laan-Luijkx, I.T. van der,, Meijer, H.A.J., Laan, S. van der,, Meijer, H.A.J.,, van der Laan-Luijkx, I. T., Meijer, H.A.J.; id_orcid, Neubert, R.E.M., Neubert, R. E. M.   +19 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Extreme heat exacerbates atmospheric ozone pollution: Holistic data-based causal investigation in China

iScience
Summary: Climate change-induced extreme heat (EH) events intensify atmospheric surface ozone (O3) pollution, posing growing threats to public health and environment. To address the lack of rigorous empirical confirmation regarding the causal impact of EH
Ruixun Xia, Qi Qi, Jiyuan Yang, Bailiang Li, Yaoqi Li, Andrew P. Morse, Tenglong Li, Qing Mu   +7 more
doaj   +1 more source

Positive feedback to regional climate enhances African wildfires

iScience, 2023
Summary: Regional climate strongly regulates the occurrence of wildfires partly because drying of fuel load increases fires. The large amounts of aerosols released by wildfires can also strongly affect regional climate.
Aoxing Zhang, Yuhang Wang, Yufei Zou
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

North American extreme precipitation events and related large-scale meteorological patterns: a review of statistical methods, dynamics, modeling, and trends [PDF]

, 2019
This paper surveys the current state of knowledge regarding large-scale meteorological patterns (LSMPs) associated with short-duration (less than 1 week) extreme precipitation events over North America. In contrast to teleconnections, which are typically
Wehner, Michael F, Richard Grotjahn, Gershunov, Alexander, Ruby Leung, Gyakum, John, Mathew Barlow, Young-Kwon Lim, Richard W. Katz, Collow, Allison, Gutowski, William, Shawn Milrad, Laurie Agel, John R. Gyakum, Min, Seung‑Ki, Gutowski, William J, Wehner, Michael, MIN, SEUNG KI, Alexander Gershunov, Agel, Laurie, Russ S. Schumacher, Milrad, Shawn, Leung, Ruby, Grotjahn, Richard, Allison Collow, Min, Seung-Ki, Schumacher, Russ, Katz, Richard, William J. Gutowski Jr, Michael F. Wehner, Barlow, Mathew, Katz, Richard W, Lim, Young-Kwon, Schumacher, Russ S, Bosilovich, Michael, Michael Bosilovich, Lim, Young‑Kwon, Gyakum, John R   +36 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Impacts of two types of ENSO on tropical cyclone tracks affecting South Korea: A clustering-based approach

iScience
Summary: The impacts of different ENSO types on tropical cyclone (TC) tracks affecting South Korea remain less understood, despite extensive studies on their influence on overall western North Pacific (WNP) TC activity.
Han-Kyoung Kim, Jong-Yeon Park, Jung-Eun Chu   +2 more
doaj   +1 more source