Results 31 to 40 of about 701,769 (305)

Linking Future Tropical Precipitation Changes to Zonally‐Asymmetric Large‐Scale Meridional Circulation

Geophysical Research Letters
Projected tropical precipitation changes by the end of the century include increased net precipitation over the Pacific Ocean and drying over the Indian Ocean, prompting ongoing debate about the underlying mechanisms.
Dana Raiter, Eli Galanti, Rei Chemke, Yohai Kaspi   +3 more
doaj   +1 more source

Extreme heat exacerbates atmospheric ozone pollution: Holistic data-based causal investigation in China

iScience
Summary: Climate change-induced extreme heat (EH) events intensify atmospheric surface ozone (O3) pollution, posing growing threats to public health and environment. To address the lack of rigorous empirical confirmation regarding the causal impact of EH
Ruixun Xia, Qi Qi, Jiyuan Yang, Bailiang Li, Yaoqi Li, Andrew P. Morse, Tenglong Li, Qing Mu   +7 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Bibliografía sobre organismos, ambientes y procesos marinos y atmosféricos en Bahía Culebra, Pacífico norte, Guanacaste, Costa Rica (1922-2012) Bibliography on marine organisms, environments, and oceanographic and atmospheric processes in Bahía Culebra, north Pacific, Costa Rica (1922-2012)

Revista de Biología Tropical, 2012
Bahía Culebra se locoaliza en la parte norte de la costa Pacífica de Costa Rica. Es una región de afloramiento estacional, rica en ambientes y organismos marinos, y además, la zona de mayor desarrollo turístico del país. En este trabajo compilo y analizo
Jorge Cortés
doaj  

Impacts of two types of ENSO on tropical cyclone tracks affecting South Korea: A clustering-based approach

iScience
Summary: The impacts of different ENSO types on tropical cyclone (TC) tracks affecting South Korea remain less understood, despite extensive studies on their influence on overall western North Pacific (WNP) TC activity.
Han-Kyoung Kim, Jong-Yeon Park, Jung-Eun Chu   +2 more
doaj   +1 more source

On Atmospheric Lapse Rates

International Journal of Aviation, Aeronautics, and Aerospace, 2019
We have derived and summarized and most important atmospheric temperature lapse rates. ALRs essentially govern vertical atmospheric air stability and creation of some cloud types.
Nihad E Daidzic
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source