Results 51 to 60 of about 223,618 (266)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Seasonal changes in surface ozone over South Korea

Heliyon, 2018
Recently, the surface ozone concentration in the Korean peninsula has been increasing more rapidly than in the past, and seasonal changes are appearing such as increases in the number of ozone alerts in springtime.
Hyun-Chae Jung, Byung-Kwon Moon, Jieun Wie   +2 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Seasonal shifts in pan-Arctic Ocean downward radiation and key drivers

iScience
Summary: The Arctic, highly sensitive to climate change, is warming rapidly due to increasing greenhouse gas emissions, resulting in a significant rise in downward radiation over the pan-Arctic Ocean in recent decades.
Yujun Liu, Haiyan Li, Yijun He, Yingying Liu   +3 more
doaj   +1 more source

Multi-technique analysis of precipitable water vapor estimates in the sub-Sahel West Africa

Heliyon, 2018
Precipitable water vapor (PWV) is an important climate parameter indicative of available moisture in the atmosphere; it is also an important greenhouse gas.
Oluwasesan A. Falaiye, Oladiran J. Abimbola, Rachel T. Pinker, Daniel Pérez-Ramírez, Alexander A. Willoughby   +4 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The Surface-Pressure Signature of Atmospheric Tides in Modern Climate Models

, 2010
Although atmospheric tides driven by solar heating are readily detectable at the earth’s surface as variations in air pressure, their simulations in current coupled global climate models have not been fully examined.
Richard S. Lindzen, Marsh, Daniel R., Curt Covey, Aiguo Dai, Dan Marsh, Dai, Aiguo, Covey, Curt, Lindzen, Richard Siegmund   +7 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Extratropical transition pathways of tropical cyclones and their associated storm intensity and destructiveness

iScience
Summary: Tropical cyclones (TCs) undergoing extratropical transition (ET) can have widespread impacts; however, the differences in their evolutionary pathways remain incompletely understood.
Hung Ming Cheung, Chang-Hoi Ho, Jung-Eun Chu   +2 more
doaj   +1 more source