Results 51 to 60 of about 11,104,205 (309)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Impacts of two types of ENSO on tropical cyclone tracks affecting South Korea: A clustering-based approach

iScience
Summary: The impacts of different ENSO types on tropical cyclone (TC) tracks affecting South Korea remain less understood, despite extensive studies on their influence on overall western North Pacific (WNP) TC activity.
Han-Kyoung Kim, Jong-Yeon Park, Jung-Eun Chu   +2 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Large-scale circulation shapes the spatial organization of anomalous precipitation over Northern Jiangsu

iScience
Summary: Anomalous precipitation events often exhibit coherent spatial organization rather than isolated intensity extremes, reshaping regional flood risk in subtropical monsoon zones.
Ying Xu, Hongyuan Fang, Wenpeng Zhao, Jian Zhang, Shuping Ma, Chuanqiao Zhou, Mingrui Shi   +6 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Seasonal changes in surface ozone over South Korea

Heliyon, 2018
Recently, the surface ozone concentration in the Korean peninsula has been increasing more rapidly than in the past, and seasonal changes are appearing such as increases in the number of ozone alerts in springtime.
Hyun-Chae Jung, Byung-Kwon Moon, Jieun Wie   +2 more
doaj   +1 more source

Mathematics in Atmospheric Sciences: An Overview [PDF]

, 2009
Several sectors of human activities rely on weather forecasts to plan in preparation of high impact weather events like snow storms, hurricanes or heat waves. Climate studies are needed to make decisions about the long-term development in agriculture, transport and land development.
openaire   +2 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Seasonal shifts in pan-Arctic Ocean downward radiation and key drivers

iScience
Summary: The Arctic, highly sensitive to climate change, is warming rapidly due to increasing greenhouse gas emissions, resulting in a significant rise in downward radiation over the pan-Arctic Ocean in recent decades.
Yujun Liu, Haiyan Li, Yijun He, Yingying Liu   +3 more
doaj   +1 more source