Results 51 to 60 of about 701,769 (305)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Seasonal shifts in pan-Arctic Ocean downward radiation and key drivers

iScience
Summary: The Arctic, highly sensitive to climate change, is warming rapidly due to increasing greenhouse gas emissions, resulting in a significant rise in downward radiation over the pan-Arctic Ocean in recent decades.
Yujun Liu, Haiyan Li, Yijun He, Yingying Liu   +3 more
doaj   +1 more source

Multi-technique analysis of precipitable water vapor estimates in the sub-Sahel West Africa

Heliyon, 2018
Precipitable water vapor (PWV) is an important climate parameter indicative of available moisture in the atmosphere; it is also an important greenhouse gas.
Oluwasesan A. Falaiye, Oladiran J. Abimbola, Rachel T. Pinker, Daniel Pérez-Ramírez, Alexander A. Willoughby   +4 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Section on the special year for mathematics of planet earth (MPE 2013)

, 2012
Dozens of research centers, foundations, international organizations and scientific societies, including the Institute of Mathematical Statistics, have joined forces to celebrate 2013 as a special year for the Mathematics of Planet Earth.
Gneiting, Tilmann
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Extratropical transition pathways of tropical cyclones and their associated storm intensity and destructiveness

iScience
Summary: Tropical cyclones (TCs) undergoing extratropical transition (ET) can have widespread impacts; however, the differences in their evolutionary pathways remain incompletely understood.
Hung Ming Cheung, Chang-Hoi Ho, Jung-Eun Chu   +2 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Web portal on environmental sciences "ATMOS'' [PDF]

Advances in Geosciences, 2006
The developed under INTAS grant web portal ATMOS (http://atmos.iao.ru and http://atmos.scert.ru) makes available to the international research community, environmental managers, and the interested public, a bilingual information source for the domain of
E. P. Gordov, V. N. Lykosov, A. Z. Fazliev   +2 more
doaj  

AERONET sun photometer as a didactic tool for understanding aerosol refractive index in the atmosphere: a case study for central Amazon [PDF]

Revista Brasileira de Ensino de Física
As the impacts of climate change become increasingly evident, understanding the role of atmospheric aerosols in regulating Earth’s climate is crucial. Despite their significance, the optical properties of aerosols remain unclear to the general public and,
Marco A. Franco, Pedro H.T. Tavares, Luciana V. Rizzo, Fernando G. Morais, Rafael Palácios, Paulo Artaxo   +5 more
doaj   +1 more source