Results 51 to 60 of about 673,580 (304)

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Grand challenges in atmospheric science [PDF]

Frontiers in Earth Science, 2013
As a subject of study, the atmospheric sciences encompass all the processes that occur in the atmosphere, together with its links with other systems, mainly the hydrosphere, cryosphere, lithosphere, biosphere, and outer space. As such it is an extensive discipline and the task of describing the main challenges is not an easy one, and entails a fair ...
openaire   +2 more sources

Atmospheres of science: Experiencing scientific mobility [PDF]

Social Studies of Science, 2020
This article uses notions of the atmospheric to engage with empirical material concerned with international mobility in science. It draws on recent conceptual work on atmospheres that frames them as allowing access to the affective qualities of everyday life and as ‘productively nebulous’: atmospheres exist between the local and the globally diffuse ...
openaire   +5 more sources

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Preface: 6th International Electronic Conference on Atmospheric Sciences

Environmental Sciences Proceedings
The sixth International Electronic Conference on Atmospheric Sciences, the range of topics will remain more general, but we are open to subject areas with a thematic topic of importance, especially interdisciplinary or transdisciplinary science [...]
Anthony R. Lupo
doaj   +1 more source

Comparing Unique Title Coverage of Web of Science and Scopus in Earth and Atmospheric Sciences.

Issues in Science and Technology Librarianship, 2012
The current journal titles in earth and atmospheric sciences, that are unique to each of two databases, Web of Science and Scopus, were identified using different methods.
Philip Barnett, Claudia Lascar
doaj   +1 more source

Decadal Changes in the Linkage Between Autumn Sea Ice and the Winter Eurasian Temperature in the 20th Century

Geophysical Research Letters, 2023
The Warm Arctic‐Cold Eurasia pattern in recent decades has attracted extensive attention and has been partly attributed to rapid sea‐ice loss; however, such a link has been unstable over the past century. Here, we use centennial reanalyzes to investigate
Xulong He, Ruonan Zhang, Shuoyi Ding, Qinglong You, Ziyi Cai   +4 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source