Results 31 to 40 of about 7,584,066 (287)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Atmospheric C/O Ratios of Sub-Neptunes with Magma Oceans: Homemade rather than Inherited

The Astrophysical Journal Letters
Recently, the James Webb Space Telescope has enabled detailed spectroscopic characterization of sub-Neptune atmospheres. With detections of carbon- and oxygen-bearing species such as CO, CO _2 , CH _4 , and H _2 O, a central question is whether the ...
Aaron Werlen, Caroline Dorn, Hilke E. Schlichting, Simon L. Grimm, Edward D. Young   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Four-dimensional variational data assimilation for inverse modelling of atmospheric methane emissions: method and comparison with synthesis inversion [PDF]

, 2008
A four-dimensional variational (4D-Var) data assimilation system for inverse modelling of atmospheric methane emissions is presented. The system is based on the TM5 atmospheric transport model.
Bergamaschi, P., M. C. Krol, P. Bergamaschi, J. F. Meirink, Krol, M.C., Dep Natuurkunde, Meirink, J., Marine and Atmospheric Research, Meirink, J.F., Krol, M. C., Meirink, J. F.   +10 more
core   +3 more sources

Sub-Neptunes Are Drier than They Seem: Rethinking the Origins of Water-rich Worlds

The Astrophysical Journal Letters
Recent claims of biosignature gases in sub-Neptune atmospheres have renewed interest in water-rich sub-Neptunes with surface oceans, often referred to as Hycean planets. These planets are hypothesized to form beyond the snow line, accreting large amounts
Aaron Werlen, Caroline Dorn, Remo Burn, Hilke E. Schlichting, Simon L. Grimm, Edward D. Young   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Do atmospheric aerosols form glasses? [PDF]

, 2008
Zobrist B, Marcolli C, Pedernera DA, Koop T. Do atmospheric aerosols form glasses? ATMOSPHERIC CHEMISTRY AND PHYSICS. 2008;8(17):5221-5244.A new process is presented by which water soluble organics might influence ice nucleation, ice growth, chemical ...
Koop, Thomas, B. Zobrist, D. A. Pedernera, Koop, T., Koop, Thomas ; https://orcid.org/, Pedernera, D. A., Marcolli, C., C. Marcolli, T. Koop, Marcolli, Claudia, Pedernera, D.A., Zobrist, Bernhard, Zobrist, B.   +12 more
core   +2 more sources

The Effects of Non-ideal Mixing in Planetary Magma Oceans and Atmospheres

The Astrophysical Journal
Sub-Neptunes with hydrogen-rich envelopes are expected to sustain long-lived magma oceans that continuously exchange volatiles with their overlying atmospheres.
Aaron Werlen, Edward D. Young, Hilke E. Schlichting, Caroline Dorn, Anat Shahar   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The Diffusion Limit of Photoevaporation in Primordial Planetary Atmospheres

The Astrophysical Journal
Photoevaporation is thought to play an important role in early planetary evolution. In this study, we investigate the diffusion limit of X-ray- and ultraviolet-induced photoevaporation in primordial atmospheres.
Darius Modirrousta-Galian, Jun Korenaga
doaj   +1 more source