Results 81 to 90 of about 1,377,493 (242)

An environmental transfer hub for multimodal atom probe tomography

, 2017
Environmental control during transfer between instruments is required for samples sensitive to air or thermal exposure to prevent morphological or chemical changes prior to analysis.
Blake Hirschi, Daniel E. Perea, Jackson Chin, Stephan S. A. Gerstl, James. E. Evans, Chin, Jackson, Gerstl, Stephan S.A., Hirschi, Blake, Evans, James. E., Perea, Daniel E.   +9 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Atomic scale analysis of light alloys using atom probe tomography

, 2016
The present paper reviews recent progress in atomic-scale characterisation of composition and nanostructure of light alloy materials using the technique of atom probe tomography.
Ross Marceau (13091346)
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

γʹ and γ″ co-precipitation phenomena in directly aged Alloy 718 with high δ-phase fractions

Materials & Design
Co-precipitation of γ′ and γ′′ is the main strengthening mechanism that provides superior high-temperature strength in directly aged Alloy 718 aerospace parts.
Vitor V. Rielli, Ehsan Farabi, Flora Godor, Christian Gruber, Aleksandar Stanojevic, Bernd Oberwinkler, Sophie Primig   +6 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Laser-Assisted Atom Probe Tomography of Deformed Minerals: A Zircon Case Study

, 2017
The application of atom probe tomography to the study of minerals is a rapidly growing area. Picosecond-pulsed, ultraviolet laser (UV-355 nm) assisted atom probe tomography has been used to analyze trace element mobility within dislocations and low-angle
Piazolo, S, Trimby, P, Cairney, JM, Yang, L, La Fontaine, A   +4 more
core   +1 more source

Deformation behavior of aluminum pillars produced by Xe and Ga focused ion beams: Insights from strain rate jump tests

Materials & Design, 2019
Micro-compression testing of focused ion beam fabricated pillars is a popular technique for mechanical characterization at small scales. However, there are concerns associated with these ion-prepared samples, including irradiation damage from Ga ions and
Y. Xiao, V. Maier-Kiener, J. Michler, R. Spolenak, J.M. Wheeler   +4 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Understanding Fragmentation of Organic Small Molecules in Atom Probe Tomography

, 2021
In atom probe tomography of molecular organic materials, field ionization of either entire molecules or molecular fragments can occur, but the mechanism governing this behavior was not previously understood. This work explains when a doubly ionized small
Jeramy D. Zimmerman (1895923), Shubham Vyas (672918), Jacob T. Bingham (11495722), Andrew P. Proudian (11592006)   +3 more
core   +1 more source