Results 51 to 60 of about 44,944 (293)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Effect of mesoporosity on thermal and mechanical properties of polystyrene/silica composites [PDF]
, 2010 In this study, mesoporous or colloidal silica particles were incorporated into polystyrene matrices via melt blending or by styrene polymerization initiated from the particle surface.
Mallapragada, Surya +6 more
core +2 more sources
Fabrication of hollow PbS nanospheres and application in phenol release [PDF]
, 2013 This article demonstrates a versatile method to prepare the hollow PbS nanospheres via the template method. First, the latex poly (vinyl benzyl chloride) (PVBC) nanoparticles were synthesized by the radical polymerization, followed by the atom transfer ...
Jian Ye, Lanping Sun, Shengping Gao
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A versatile platform for precise synthesis of asymmetric molecular brush in one shot
Nature Communications, 2017 Producing well-defined polymer compositions and structures facilitates their use in many different applications. Here the authors show the synthesis of well-defined asymmetric double-brushes by a one-pot concurrent atom transfer radical polymerization ...
Binbin Xu, Chun Feng, Xiaoyu Huang
doaj +1 more source
Polymerization-Induced Self-Assembly for Efficient Fabrication of Biomedical Nanoplatforms
Research, 2023 Amphiphilic copolymers can self-assemble into nano-objects in aqueous solution. However, the self-assembly process is usually performed in a diluted solution (
Xiaopeng Zhao +6 more
doaj +1 more source
Design of new highly functional polymer grafted polyhipes for proteins immobilization [PDF]
, 2012 PolyHIPE have proven to be useful in a large variety of applications included column filtration/separation, supported organic chemistry, as media for tissue engineering and 3D cell culture.1 The ability to conveniently modify pHIPE surfaces with ...
Audouin, Fabrice +4 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Ab Initio Emulsion Atom‐Transfer Radical Polymerization
Angewandte Chemie, 2018 AbstractStable latexes of poly(meth)acrylates with predetermined molecular weights, narrow molecular‐weight distributions, and controlled architecture were prepared by true ab initio emulsion atom‐transfer radical polymerization. Water‐soluble (macro)initiators in combination with a hydrophilic catalyst, Cu/tris(2‐pyridylmethyl)amine, initiated the ...
Lorandi F. +3 more
openaire +4 more sources