Results 51 to 60 of about 410,646 (334)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Energy dissipation in multifrequency atomic force microscopy
Beilstein Journal of Nanotechnology, 2014 The instantaneous displacement, velocity and acceleration of a cantilever tip impacting onto a graphite surface are reconstructed. The total dissipated energy and the dissipated energy per cycle of each excited flexural mode during the tip interaction is
Valentina Pukhova +2 more
doaj +1 more source
Atomic force microscopy: A nanobiotechnology for cellular research
Nano TransMed, 2022 : Nanobiotechnology such as atomic force microscopy (AFM) has a great application in various regimes of cell biology, offering an excellent avenue to study cellular nanotopography, nanomechanics, and nanointeraction. AFM nanotopography can provide a high
Guangzhao Guan, Yan He, Li Mei
doaj +1 more source
The CantiClever: a dedicated probe for magnetic force microscopy [PDF]
, 2002 We present a new cantilever for magnetic-force microscopy (MFM), the CantiClever, which is not derived from atomic-force microscopy (AFM) probes but optimized for MFM.
Abelmann, Leon +5 more
core +4 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Repulsive bimodal atomic force microscopy on polymers
Beilstein Journal of Nanotechnology, 2012 Bimodal atomic force microscopy can provide high-resolution images of polymers. In the bimodal operation mode, two eigenmodes of the cantilever are driven simultaneously.
Alexander M. Gigler +5 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Magnetic-Dielectric Cantilevers for Atomic Force Microscopy
NanomaterialsAtomic force microscopy (AFM) is a technique that relies on detecting forces at the nanonewton scale. It involves using a cantilever with a tiny tip at one end. This tip interacts with the short- and long-range forces of material surfaces.
Gala Sanchez-Seguame +7 more
doaj +1 more source
Progress in the Correlative Atomic Force Microscopy and Optical Microscopy
Sensors, 2017 Atomic force microscopy (AFM) has evolved from the originally morphological imaging technique to a powerful and multifunctional technique for manipulating and detecting the interactions between molecules at nanometer resolution.
Lulu Zhou +3 more
doaj +1 more source
Practical applications of atomic force microscopy in biomedicine
STEMedicine, 2020 The last thirty years of progress of atomic force microscopy (AFM) applied to living matter is reviewed with a focus on potential uses in drug discovery or screening of patient samples.
Nicola Galvanetto
doaj +1 more source