Results 71 to 80 of about 7,409,393 (390)

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Developing an Integrated Model of Resilience and System Dynamics for NPP Accident [PDF]

Journal of Systems Thinking in Practice
The Fukushima Daiichi nuclear power plant (FDNPP) accident highlights the role of resilience and system dynamics in maintaining the safety of nuclear power plants (NPP).
Muhammed Mufazzal Hossen
doaj   +1 more source

A Comparative Analysis of Neutron Transport Calculations Based on Variational Formulation and Finite Element Approaches

Energies, 2020
The application of continuous and discontinuous approaches of the finite element method (FEM) to the neutron transport equation (NTE) has been investigated.
Khashayar Sadeghi, Seyed Hadi Ghazaie, Ekaterina Sokolova, Ahmad Zolfaghari, Mohammad Reza Abbasi   +4 more
doaj   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Investigations on strength of piping for non-condensable gas combustion (Part 2: FEM analysis of steel pipes with a valve or an elbow subjected to hydrogen-oxygen detonation)

Nihon Kikai Gakkai ronbunshu, 2015
Carbon steel pipe specimens, which had been experimentally ruptured or deformed by hydrogen-oxygen detonation, were analysed by dynamic analysis using a finite element method (FEM).
Akira NEBU, Koji YAMADA, Koji DOZAKI, Akitaka HIDAKA, Masahiro UCHIDA, Takahiro SONE   +5 more
doaj   +1 more source

Atomic Layer Tailoring Titanium Carbide MXene To Tune Transport and Polarization for Utilization of Electromagnetic Energy beyond Solar and Chemical Energy.

ACS Applied Materials and Interfaces, 2019
The utilization of electromagnetic (EM) energy neither is affected by the weather nor produces harmful substances. How to utilize and convert EM energy is of practical concern.
P. He, M. Cao, Jincheng Shu, Yong Cai, Xi-Xi Wang, Quan‐Liang Zhao, Jie Yuan   +6 more
semanticscholar   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Analysis of Steam Line Break Accident Using PCTRAN Model of VVER-1200 NPP

Applications of Modelling and Simulation, 2023
The investigation of thermal-hydraulic parameters during steam-line break (SLB) accidents is performed by applying the personal computer transient analyzer (PCTRAN) simulator model of the VVER-1200 nuclear power plant (NPP). Five cases, namely, 0.005 m2 (
Muhammed Mufazzal Hossen, M. Khalaquzzaman, S. K. Anisur Rahman   +2 more
doaj  

Investigations on strength of piping for non-condensable gas combustion (Part 3: Estimation of fracture strain of steel pipes subjected to hydrogen-oxygen detonation)

Nihon Kikai Gakkai ronbunshu, 2015
To assess the integrity of piping under the detonation pressure of accumulated hydrogen-oxygen, the fracture strain of the pipe material must be identified.
Akira NEBU, Koji YAMADA, Koji DOZAKI, Akitaka HIDAKA, Masahiro UCHIDA, Takahiro SONE   +5 more
doaj   +1 more source