Results 71 to 80 of about 818,442 (297)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Developing an Integrated Model of Resilience and System Dynamics for NPP Accident [PDF]
Journal of Systems Thinking in PracticeThe Fukushima Daiichi nuclear power plant (FDNPP) accident highlights the role of resilience and system dynamics in maintaining the safety of nuclear power plants (NPP).
Muhammed Mufazzal Hossen
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2015 Carbon steel pipe specimens, which had been experimentally ruptured or deformed by hydrogen-oxygen detonation, were analysed by dynamic analysis using a finite element method (FEM).
Akira NEBU +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Russian Journal of Economics and Law, 2007 The article is dedicated to the analysis of certain signs of the objective part of corpus delicti of the safety regulations violations at the atomic power objects: the deed, its consequences, casual relations between them, crime scene.
R. R. Fazylov
doaj
Nihon Kikai Gakkai ronbunshu, 2015 To assess the integrity of piping under the detonation pressure of accumulated hydrogen-oxygen, the fracture strain of the pipe material must be identified.
Akira NEBU +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Analysis of Steam Line Break Accident Using PCTRAN Model of VVER-1200 NPP
Applications of Modelling and Simulation, 2023 The investigation of thermal-hydraulic parameters during steam-line break (SLB) accidents is performed by applying the personal computer transient analyzer (PCTRAN) simulator model of the VVER-1200 nuclear power plant (NPP). Five cases, namely, 0.005 m2 (
Muhammed Mufazzal Hossen +2 more
doaj
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source