Results 81 to 90 of about 199,926 (265)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hydrogen photoionization in a magnetized medium: The rigid-wavefunction approach revisited

Astronomy & Astrophysics
Realistic modeling of stellar spectra requires accurate radiative opacity coefficients. Owing to the fragmentary nature of existing data from rigorous quantum-mechanical calculations, photoionization coefficients based on the rigid-wavefunction ...
Rohrmann René D.
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

XRISM reveals a variable, multi-phase outflow-inflow structure during the 2024 X-ray obscured outburst of black hole transient V4641 Sgr

Astronomy & Astrophysics
We report the results of a simultaneous X-ray and optical spectroscopy campaign on the Galactic black hole X-ray binary (BH XRB) V4641 Sgr, carried out with XRISM and the Seimei telescope during a low-luminosity phase toward the end of its 2024 outburst.
Parra M., Shidatsu M., Tomaru R., Done C., Muñoz-Darias T., Armas Padilla M., Ogawa S., Marino A., Grollimund N., Corbel S., De la Fuente E., Cheng H., Díaz Trigo M., Fender R., Isogai K., Kobayashi S. B., Motta S. E., Murata K., Negoro H., Safi-Harb S., Suzuki H., Tsuji N., Ueda Y., Wang X., Zhang C., Zhang Y., Zhang Z.   +26 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Dissociative ionization cross-sections and the rate coefficients of H2S, OCS, LiH, and SiC

Astronomy & Astrophysics
Context. Electron-molecule and positron-molecule interactions play a major role in the interstellar medium. Although several inelastic channels have been studied in the literature, dissociative ionization studies of molecules are scarce. Aims.
Shanmugasundaram Suriyaprasanth, Dharmalingam Geetha, Graves Vincent, Gupta Dhanoj   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Radiative accelerations of nickel from new monochromatic opacities

Astronomy & Astrophysics
Context. Radiative accelerations express the transfer of momentum from the radiation field to the various chemical species of the stellar medium. They are evaluated from the monochromatic cross-sections of each element given the local thermodynamical ...
Hui-Bon-Hoa A., Pain J.-C.
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source