Results 41 to 50 of about 183,525 (253)

Capturing coherent pseudorotation through conical intersection in photoionized benzene

Nature Communications
Vibronic coupling and coherence are crucial in the charge and energy transfer of photoexcited molecules. Here we investigate the coupled electron-nuclear dynamics of the photoionized benzene molecule using the time-resolved Coulomb-explosion imaging ...
Zejin Liu, Ming Zhang, Tianyu Zhou, Xiaokai Li, Shengpeng Zhou, Lu Wu, Yizhang Yang, Jiaqi Zhou, Lanhai He, Dongdong Zhang, Xueguang Ren, Alexander I. Kuleff, Oriol Vendrell, Kiyoshi Ueda, Zheng Li, Dajun Ding, Chuncheng Wang   +16 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Atomic partial wave meter by attosecond coincidence metrology

Nature Communications, 2022
Understanding the photoelectron emission time after the interaction of photon with atoms and molecules is of fundamental interest. Here the authors examine the role of partial waves to the photoionization phase shift of atoms using an attosecond clock ...
Wenyu Jiang, Gregory S. J. Armstrong, Jihong Tong, Yidan Xu, Zitan Zuo, Junjie Qiang, Peifen Lu, Daniel D. A. Clarke, Jakub Benda, Avner Fleischer, Hongcheng Ni, Kiyoshi Ueda, Hugo W. van der Hart, Andrew C. Brown, Xiaochun Gong, Jian Wu   +15 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Biophotonics in veterinary medicine: current clinical applications, translational challenges, and emerging opportunities

Frontiers in Veterinary Science
Biophotonics, a relatively new scientific field, applies optical or light-based techniques to biology and medicine. These approaches enable non-invasive visualization, monitoring, and characterization of biological tissues and processes, thereby ...
Daira Viškere, Daira Viškere, Ilze Matise-VanHoutan, Ilze Matise-VanHoutan, Blaz Cugmas, Mindaugas Tamosiunas   +5 more
doaj   +1 more source

METHOD DEVELOPMENT FOR THE ELEMENTAL ANALYSIS OF ORGANIC RICH SOIL SAMPLES BY MICROWAVE PLASMA ATOMIC EMISSION SPECTROMETRY

Studia Universitatis Babes-Bolyai Chemia, 2017
In this study, the method development is described for the multi elemental determination of organic rich soil reference material (BCR 700) by the new microwave plasma atomic emission spectrometry (MP-AES).
Csilla Noémi TÓTH, Sándor HARANGI, Anikó KÁROLYI, István FÁBIÁN, Edina BARANYAI   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source