Results 51 to 60 of about 244,391 (301)

Identification of binding mechanisms in single molecule-DNA complexes [PDF]

open access: yes, 2003
Eckel R, Ros R, Ros A, Wilking SD, Sewald N, Anselmetti D. Identification of binding mechanisms in single molecule-DNA complexes. Biophysical journal. 2003;85(3):1968-1973.Changes in the elastic properties of single deoxyribonucleic acid (DNA) molecules ...
Anselmetti, Dario   +14 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Development of a reusuable atomic oxygen sensor using oxide thick films [PDF]

open access: yes, 2009
The aim of this project was to develop a thick film sensor made of zinc oxide that would accurately respond to various fluxes of atomic oxygen (AO), allowing it to be regenerated after saturation.
Valer, Juan Carlos
core  

Quantification of Water Content in Glass at Nanoscale Using Atom Probe Tomography [PDF]

open access: yes
Water is a critical volatile component in planetary bodies and plays a key role in the Earth's dynamic evolution. Traditional methods to analyze water in either mineral or glass phases are usually limited to areas larger than 10 microns.
Yang, Ya-Nan   +3 more
core   +1 more source

Skin malformation assessment by triple wavelength imaging

open access: yesFrontiers in Medicine
This invited paper reviews recent results achieved by snapshot triple wavelength imaging of skin, a method ensuring high spectral and spatial resolution within sub-second imaging time, avoiding motion artefacts in the spectral image sets.
Janis Spigulis   +4 more
doaj   +1 more source

THE DEVELOPMENT OF ANALYTICAL METHODS FOR THE ELEMENTAL DETERMINATION OF BIOTIC INDICATORS PRESENT IN AQUATIC ECOSYSTEMS

open access: yesStudia Universitatis Babes-Bolyai Chemia, 2017
In our research, we investigate the accumulation extent of the inorganic contaminants accessing the aquatic food chain, including zooplankton and fish species through model experiments.
Petra HERMAN   +4 more
doaj   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

A Cross-Sectional Study of the Dermatological Manifestations of Patients with Fabry Disease and the Assessment of Angiokeratomas with Multimodal Imaging

open access: yesDiagnostics, 2023
Fabry disease (FD) is a multisystemic X-linked lysosomal storage disease that presents with angiokeratomas (AKs). Our objective was to investigate the clinical and morphologic features of AKs and to present two experimental techniques, multispectral ...
Pálma Anker   +9 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

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