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Atopic dermatitis: an expanding therapeutic pipeline for a complex disease
Nature reviews. Drug discovery, 2021 Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains challenging to treat owing to the limited response to available therapies.
T. Bieber
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Molecular Mechanisms of Atopic Dermatitis Pathogenesis
International Journal of Molecular Sciences, 2021 Atopic dermatitis is a chronic, non-infectious inflammatory dermatosis. Acharacteristic feature is persistent itching of the skin. The chronic, relapsing course of the disease, economic burden, and the whole family’s involvement in the treatment process ...
Jowita Sroka-Tomaszewska, M. Trzeciak
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Acta Dermato-Venereologica, 2023 Clinical trials showed that upadacitinib, a selective Janus kinase-1 inhibitor, is effective for treatment of moderate-to-severe atopic dermatitis. However, daily practice studies are limited.
Celeste M. Boesjes +8 more
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Oral food challenges in children [PDF]
Korean Journal of Pediatrics, 2011 Many patients assume that allergic reactions against foods are responsible for triggering or worsening their allergic symptoms. Therefore, it is important to identify patients who would benefit from an elimination diet, while avoiding unnecessary dietary
Hye Yung Yum +9 more
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Frontiers in Immunology, 2022 CARD11-associated diseases are monogenic inborn errors of immunity involving immunodeficiency, predisposition to malignancy and immune dysregulation such as lymphoproliferation, inflammation, atopic and autoimmune manifestations.
Luciano Urdinez +26 more
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Atmosphere, 2020 Precise exposure assessment of air pollutants is crucial in epidemiologic studies to ensure valid estimates of health effects. We conducted a longitudinal study to evaluate the role of air quality monitoring (AQM) measurements and high-resolution ...
Young-Min Kim +4 more
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Atopic Dermatitis, food allergy and dietary interventions. A tale of controversy [PDF]
Anais Brasileiros de Dermatologia, 2013 Atopic Dermatitis has long been a controversial entity in regard its relationship to food allergy. Indeed, inter-discipline disparity in the way dermatologists and allergologists perceive the food allergy/atopic dermatitis interplay, hampers the design ...
George V. Guibas +4 more
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British Journal of Dermatology, 2020 Tralokinumab, a fully human monoclonal antibody, specifically neutralizes interleukin‐13, a key cytokine driving peripheral inflammation in atopic dermatitis (AD). In phase II studies, tralokinumab combined with topical corticosteroids provided early and
A. Wollenberg +21 more
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Prevalence and Incidence of Atopic Dermatitis: A Systematic Review
Acta Dermato-Venereologica, 2020 The primary objective of this study was to systematically review and analyse epidemiological studies of the prevalence and incidence of atopic dermatitis (AD) during childhood and adulthood, focusing on data from the 21st century.
Simon B A Bylund +3 more
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IL1RL1 single nucleotide polymorphisms are associated with asthma in the Iranian population
Monaldi Archives for Chest Disease, 2021 Asthma is a chronic and multifactorial disease which is known to result from environmental and genetic factors. Interleukin 1 receptor-like 1 (IL1RL1) is a receptor, which promotes inflammatory responses after binding to its ligand IL-33. Several studies
Maral Ranjbar +5 more
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