Results 1 to 10 of about 59,745 (273)

Atopic Features and Inflammatory Markers Across Cassano-Graded Adenoid Hypertrophy [PDF]

Children
Background: Evidence linking adenoid hypertrophy (AH) and atopy is conflicting. We examined whether Cassano-graded AH severity is more closely associated with inflammatory markers than with IgE-mediated sensitization. Methods: We retrospectively included
Fatih Kaplan, Bilge Kurnaz Kaplan, Abdulgani Gülyüz   +2 more
doaj   +2 more sources

The protective role of conjunctival goblet cell mucin sialylation

Nature Communications, 2023
Conjunctival goblet cells secrete mucins that are heavily glycosylated. Here, the authors show that sialylation of mucins is essential for capturing and encapsulates allergen particles and thus reduces the risk for developing allergic conjunctivitis.
Moe Matsuzawa, Tomoaki Ando, Saaya Fukase, Meiko Kimura, Yasuharu Kume, Takuma Ide, Kumi Izawa, Ayako Kaitani, Mutsuko Hara, Eri Nakamura, Anna Kamei, Akira Matsuda, Nobuhiro Nakano, Keiko Maeda, Norihiro Tada, Hideoki Ogawa, Ko Okumura, Akira Murakami, Nobuyuki Ebihara, Jiro Kitaura   +19 more
doaj   +1 more source

Development of mouse model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens: ragweed pollen cross-reacts with fennel and black pepper

Frontiers in Immunology, 2022
Oral allergy syndrome (OAS) is an IgE-mediated immediate food allergy that is localized to the oral mucosa. Pollen food allergy syndrome (PFAS), a pollinosis-associated OAS, is caused by cross-reactivity between food and pollen allergens.
Anna Kamei, Anna Kamei, Kumi Izawa, Tomoaki Ando, Ayako Kaitani, Risa Yamamoto, Akie Maehara, Takuma Ide, Takuma Ide, Hiromichi Yamada, Hiromichi Yamada, Mayuki Kojima, Mayuki Kojima, Hexing Wang, Hexing Wang, Koji Tokushige, Koji Tokushige, Nobuhiro Nakano, Toshiaki Shimizu, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Jiro Kitaura   +22 more
doaj   +1 more source

Murine model identifies tropomyosin as IgE cross-reactive protein between house dust mite and coho salmon that possibly contributes to the development of salmon allergy

Frontiers in Immunology, 2023
BackgroundRecently, we have developed a method to identify IgE cross-reactive allergens. However, the mechanism by which IgE cross-reactive allergens cause food allergy is not yet fully understood how. In this study, we aimed to understand the underlying
Risa Yamamoto, Kumi Izawa, Tomoaki Ando, Ayako Kaitani, Atsushi Tanabe, Hiromichi Yamada, Hiromichi Yamada, Shino Uchida, Shino Uchida, Akihisa Yoshikawa, Akihisa Yoshikawa, Yasuharu Kume, Yasuharu Kume, Shun Toriumi, Shun Toriumi, Akie Maehara, Hexing Wang, Hexing Wang, Masakazu Nagamine, Naoko Negishi, Nobuhiro Nakano, Nobuyuki Ebihara, Toshiaki Shimizu, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Jiro Kitaura, Jiro Kitaura   +27 more
doaj   +1 more source

Intractable Itch in Atopic Dermatitis: Causes and Treatments

Biomedicines, 2021
Itch or pruritus is the hallmark of atopic dermatitis and is defined as an unpleasant sensation that evokes the desire to scratch. It is also believed that itch is a signal of danger from various environmental factors or physiological abnormalities ...
Yoshie Umehara, Chanisa Kiatsurayanon, Juan Valentin Trujillo-Paez, Panjit Chieosilapatham, Ge Peng, Hainan Yue, Hai Le Thanh Nguyen, Pu Song, Ko Okumura, Hideoki Ogawa, François Niyonsaba   +10 more
doaj   +1 more source

Staphylococcus aureus δ-toxin present on skin promotes the development of food allergy in a murine model

Frontiers in Immunology, 2023
BackgroundPatients with food allergy often suffer from atopic dermatitis, in which Staphylococcus aureus colonization is frequently observed. Staphylococcus aureus δ-toxin activates mast cells and promotes T helper 2 type skin inflammation in the tape ...
Hiromichi Yamada, Hiromichi Yamada, Ayako Kaitani, Kumi Izawa, Tomoaki Ando, Anna Kamei, Anna Kamei, Shino Uchida, Shino Uchida, Akie Maehara, Mayuki Kojima, Mayuki Kojima, Risa Yamamoto, Hexing Wang, Hexing Wang, Masakazu Nagamine, Keiko Maeda, Keiko Maeda, Koichiro Uchida, Koichiro Uchida, Nobuhiro Nakano, Yoshikazu Ohtsuka, Hideoki Ogawa, Ko Okumura, Toshiaki Shimizu, Toshiaki Shimizu, Jiro Kitaura, Jiro Kitaura   +27 more
doaj   +1 more source

Tuning IgE: IgE-Associating Molecules and Their Effects on IgE-Dependent Mast Cell Reactions

Cells, 2021
The recent emergence of anti-immunoglobulin E (IgE) drugs and their candidates for humans has endorsed the significance of IgE-dependent pathways in allergic disorders.
Tomoaki Ando, Jiro Kitaura
doaj   +1 more source

Topical Gynura procumbens as a Novel Therapeutic Improves Wound Healing in Diabetic Mice

Plants, 2021
Nonhealing wounds are major socioeconomic challenges to healthcare systems worldwide. Therefore, there is a substantially unmet need to develop new drugs for wound healing.
Nutda Sutthammikorn, Volaluck Supajatura, Hainan Yue, Miho Takahashi, Sunee Chansakaow, Nobuhiro Nakano, Pu Song, Takasuke Ogawa, Shigaku Ikeda, Ko Okumura, Hideoki Ogawa, François Niyonsaba   +11 more
doaj   +1 more source

Epicutaneous Administration of Papain Induces IgE and IgG Responses in a Cysteine Protease Activity-Dependent Manner

Allergology International, 2014
Background: Epicutaneous sensitization to allergens is important in the pathogenesis of not only skin inflammation such as atopic dermatitis but also "atopic march" in allergic diseases such as asthma and food allergies.
Hideo Iida, Toshiro Takai, Yusuke Hirasawa, Seiji Kamijo, Sakiko Shimura, Hirono Ochi, Izumi Nishioka, Natsuko Maruyama, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda   +10 more
doaj   +1 more source

Mucosal Mast Cells as Key Effector Cells in Food Allergies

Cells, 2022
Mucosal mast cells (MMCs) localized in the intestinal mucosa play a key role in the development of IgE-mediated food allergies. Recent advances have revealed that MMCs are a distinctly different population from connective tissue mast cells localized in ...
Nobuhiro Nakano, Jiro Kitaura
doaj   +1 more source