Results 11 to 20 of about 65,128 (311)

Topical Gynura procumbens as a Novel Therapeutic Improves Wound Healing in Diabetic Mice

Plants, 2021
Nonhealing wounds are major socioeconomic challenges to healthcare systems worldwide. Therefore, there is a substantially unmet need to develop new drugs for wound healing.
Nutda Sutthammikorn, Volaluck Supajatura, Hainan Yue, Miho Takahashi, Sunee Chansakaow, Nobuhiro Nakano, Pu Song, Takasuke Ogawa, Shigaku Ikeda, Ko Okumura, Hideoki Ogawa, François Niyonsaba   +11 more
doaj   +1 more source

Epicutaneous Administration of Papain Induces IgE and IgG Responses in a Cysteine Protease Activity-Dependent Manner

Allergology International, 2014
Background: Epicutaneous sensitization to allergens is important in the pathogenesis of not only skin inflammation such as atopic dermatitis but also "atopic march" in allergic diseases such as asthma and food allergies.
Hideo Iida, Toshiro Takai, Yusuke Hirasawa, Seiji Kamijo, Sakiko Shimura, Hirono Ochi, Izumi Nishioka, Natsuko Maruyama, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda   +10 more
doaj   +1 more source

Mucosal Mast Cells as Key Effector Cells in Food Allergies

Cells, 2022
Mucosal mast cells (MMCs) localized in the intestinal mucosa play a key role in the development of IgE-mediated food allergies. Recent advances have revealed that MMCs are a distinctly different population from connective tissue mast cells localized in ...
Nobuhiro Nakano, Jiro Kitaura
doaj   +1 more source

The clinical meaning of histamine skin reactivity [PDF]

, 2015
The definition of the “atopic state”, i.e. subjects presenting at least one skin wheal with a minimum diameter of 3 mm induced by an allergen skin-prick test (ASPT), is based on the assumption that wheal size depends entirely on the amount of histamine
BARRETO, Mario, RONCHETTI, ROBERTO
core   +1 more source

Enzyme-Linked Immunosorbent Assays with High Sensitivity for Antigen-Specific and Total Murine IgE: A Useful Tool for the Study of Allergies in Mouse Models

Allergology International, 2009
Background: In studies on allergies in mouse models, IgE production is an essential parameter to be evaluated. Here, we examine the effect of commercially available immunoreaction enhancer solutions and different blocking reagents in enzyme-linked ...
Toshiro Takai, Yuri Ochiai, Saori Ichikawa, Emi Sato, Takasuke Ogawa, Tomoko Tokura, Takatoshi Kuhara, Hiroshi Kawai, Hideki Hatanaka, Seizo Takahashi, Hideoki Ogawa, Ko Okumura   +11 more
doaj   +1 more source

The Antimicrobial Peptide Human β-Defensin-3 Accelerates Wound Healing by Promoting Angiogenesis, Cell Migration, and Proliferation Through the FGFR/JAK2/STAT3 Signaling Pathway

Frontiers in Immunology, 2021
In addition to its antimicrobial activity, the skin-derived antimicrobial peptide human β-defensin-3 (hBD-3) promotes keratinocyte proliferation and migration to initiate the wound healing process; however, its effects on fibroblasts, which are the major
Miho Takahashi, Miho Takahashi, Yoshie Umehara, Hainan Yue, Hainan Yue, Juan Valentin Trujillo-Paez, Ge Peng, Ge Peng, Hai Le Thanh Nguyen, Hai Le Thanh Nguyen, Risa Ikutama, Risa Ikutama, Ko Okumura, Hideoki Ogawa, Hideoki Ogawa, Shigaku Ikeda, Shigaku Ikeda, François Niyonsaba, François Niyonsaba   +18 more
doaj   +1 more source

Staphylococcal enterotoxin sensitization in a community-based population : a potential role in adult-onset asthma [PDF]

, 2014
Background: Recent studies suggest that Staphylococcus aureus enterotoxin sensitization is a risk factor for asthma. However, there is a paucity of epidemiologic evidence on adult-onset asthma in community-based populations.
Bachert, Claus, Chang, Yoon-Seok, Cho, Sang-Heon, Choi, Min-Ho, Kang, Hye-Ryun, Kim, Sae-Hoon, Lim, Min Kyung, Min, Kyung-Up, Park, Heung-Woo, Song, Woo-Jung, Tomassen, Peter, Yun, E Hwa   +11 more
core   +2 more sources

Insulin Resistance Increases Serum Immunoglobulin E Sensitization in Premenopausal Women [PDF]

Diabetes & Metabolism Journal, 2021
Background Although studies have shown that obesity is associated with aeroallergen sensitization (atopy), controversy still exists. We aimed to investigate the association between metabolic status, obesity, and atopy stratified by sex and menopausal ...
Seung Eun Lee, Ji Yeon Baek, Kyungdo Han, Eun Hee Koh   +3 more
doaj   +1 more source

Pollen grains induce a rapid and biphasic eczematous immune response in atopic eczema patients [PDF]

, 2008
Introduction: Eczematous reactions to type I allergy-inducing antigens are documented in a subgroup of patients with atopic eczema. Yet, the underlying immunological mechanisms are not well understood.
Behrendt, Heidrun, Darsow, Ulf, Eyerich, Kilian, Foerster, Stefanie, Huss-Marp, Johannes, Ring, Johannes, Traidl-Hoffmann, Claudia, Wollenberg, Andreas   +7 more
core   +2 more sources

A systematic review of associations between environmental exposures and development of asthma in children aged up to 9 years [PDF]

, 2014
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Peer reviewedPublisher ...
AlKandari, F, Ayres, J G, Cowie, H, Dick, S, Doust, E, Dynes, K, Friend, A, Turner, S W   +7 more
core   +1 more source