Results 21 to 30 of about 65,128 (311)

Involvement of PU.1 in NFATc1 promoter function in osteoclast development

Allergology International, 2015
Background: The transcription factors NFATc1 and PU.1 play important roles in osteoclast development. NFATc1 and PU.1 transactivate osteoclast-specific gene expression and a deficiency in NFATc1 or PU.1 genes causes osteopetrosis due to an insufficient ...
Kentaro Ishiyama, Takuya Yashiro, Nobuhiro Nakano, Kazumi Kasakura, Ryosuke Miura, Mutsuko Hara, Fumitaka Kawai, Keiko Maeda, Naoto Tamura, Ko Okumura, Hideoki Ogawa, Yoshinari Takasaki, Chiharu Nishiyama   +12 more
doaj   +1 more source

Distinguishing Asthma Phenotypes Using Machine Learning Approaches. [PDF]

, 2015
Asthma is not a single disease, but an umbrella term for a number of distinct diseases, each of which are caused by a distinct underlying pathophysiological mechanism. These discrete disease entities are often labelled as asthma endotypes.
A Custovic, A Custovic, A Fraser, A Høst, A Pickles, A Simpson, A Wijga, Adnan Custovic, AJ Lowe, AV Berg, B Clarisse, BD Spycher, BD Spycher, BD Spycher, BG Toelle, BL Jones, BL Jones, C-M Chen, CA Figueiredo, CE Kuehni, CJ Lodge, CL Storr, D Barber, D Belgrave, D Caudri, D Nagin, DA Linzer, DC Belgrave, DC Belgrave, DCM Belgrave, DCM Belgrave, F Kauffmann, F Kauffmann, FD Martinez, FL Garden, FP Perera, G Bochenek, G Weinmayr, GB Marks, GP Anderson, J Hagenaars, J Henderson, J Lotvall, J Magidson, J Sunyer, J Winn, JA Smith, JK Vermunt, K Burnham, KE Wonderen Van, KL Nylund, L García-Marcos Álvarez, L Hunt, L Lowe, L Panico, LA Lowe, M Depner, M Herr, M Scott, Magnus Rattray, Mattia Prosperi, MJ Ege, ML Barreto, MM Hagendorens, MW Pijnenburg, N Lazic, NC Nicolaou, NG Papadopoulos, OE Savenije, P Burney, P Haldar, P Rzehak, P Rzehak, PD Sly, Q Chen, Q Vuong, Rebecca Howard, RJP Valk van der, RL Bergmann, RL Miller, RO Crapo, RT Stein, S American Thoracic, S Havstad, S Mihrshahi, S Rabe-Hesketh, S Stanojevic, SE Wenzel, SK Weiland, ST Lanza, ST Lanza, T Jung, T Minka, The European Community Respiratory Health Survey, V Siroux, WC Moore, X Robin, Y Lo   +97 more
core   +2 more sources

Involvement of PU.1 in Mast Cell/Basophil-Specific Function of the Human IL1RL1/ST2 Promoter

Allergology International, 2012
Background: The human IL1RL1/ST2 gene encodes IL33 receptor. Recently, IL33 has been recognized as a key molecule for the development of Th2 response. Although mast cells and basophils are major targets of IL33 and play important roles in IL33-mediated ...
Yosuke Baba, Keiko Maeda, Takuya Yashiro, Eisuke Inage, Frangois Niyonsaba, Mutsuko Hara, Ryuyo Suzuki, Yoshikazu Ohtsuka, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Chiharu Nishiyama   +11 more
doaj   +1 more source

A comprehensive analysis of interleukin-4 receptor polymorphisms and their association with atopy and IgE regulation in childhood [PDF]

, 2004
Background: The interleukin (IL) 4/IL13 pathway is involved in the regulation of IgE production associated with atopic diseases. Numerous polymorphisms have been identified in the coding region of the IL4 receptor alpha chain (IL4Ra) and previous ...
Carr, David, Fritzsch, Christian, Kabesch, Michael, Mutius, Erika von, Schmid, Irene, Stachel, Daniel, Weiland, Stephan K., Woitsch, Bernd   +7 more
core   +1 more source

Independent and interactive effects of eye rubbing and atopy on keratoconus

Frontiers in Immunology, 2022
PurposeTo evaluate the independent and interactive effects of eye rubbing and atopy on keratoconus (KC) in central China.MethodsA total of 330 KC patients and 330 controls were recruited in the case-control study.
Kaili Yang, Dan Li, Liyan Xu, Chenjiu Pang, Dongqing Zhao, Shengwei Ren   +5 more
doaj   +1 more source

FADS Gene Cluster Polymorphisms: Important Modulators of Fatty Acid Levels and Their Impact on Atopic Diseases [PDF]

, 2009
Long-chain polyunsaturated fatty acids (LC-PUFAs) play an important role in several physiological processes and their concentration in phospholipids has been associated with several complex diseases, such as atopic disease.
Heinrich, Joachim, Illig, Thomas, Koletzko, Berthold, Lattka, Eva   +3 more
core   +1 more source

Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis. [PDF]

, 2014
BACKGROUND: The association between atopy and asthma is attenuated in non-affluent populations, an effect that may be explained by childhood infections such as geohelminths.
Barreto, ML, Chico, ME, Cooper, PJ, Endara, P, Platts-Mills, TA, Rodrigues, LC, Vaca, M, Workman, L   +7 more
core   +1 more source

Allergic Disorders in Africa and Africans: Is it Primarily a Priority? [PDF]

, 2010
In Africa, the burden of some diseases has been a problem for centuries. The spectrum of African diseases includes allergies, infections, nutritional deficiencies, and natural disasters.
Adams, Araujo, Araujo, Asmah, Breman, Brugman, Butler, Carvalho, Chaisson, Cooper, Cooper, Cooper, Cullinan, Dagoye, Dagoye, Du Toit, Erasto Vitus Mbugi, Estmbale, Gadermaier, Grant, Jaffu Othniel Chilongola, Jeannin, Jeebhay, Jeebhay, Kamradt, Linneberg, Linneberg, Lopata, Lynch, Lynch, Madsen, Marshall, Matricardi, Matricardi, Mercer, Modjarrad, Moore, Motala, Ndiaye, Nicolaou, Nyan, Obeng, Obihara, Obihara, Obihara, Obihara, Obihara, Obihara, Okano, Pacifico, Palyvos, Pawankar, Platts-Mills, Potter, Potter, Potter, Potter, Rauter, Riedler, Scrivener, Sibanda, Sibanda, Steinman, Thyssen, Tohon, van den Biggelaar, van den Biggelaar, van den Biggelaar, van der Kleij, van Niekerk, Van Niekerk, Veien, Veien, Vergara, Weinberg, Westritschnig, Wuthrich, Yazdanbakhsh, Yazdanbakhsh, Yazdanbakhsh, Zar   +80 more
core   +1 more source

Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury

Scientific Reports, 2021
The prognosis of the liver transplant patients was frequently deteriorated by ischemia and reperfusion injury (IRI) in the liver. Infiltration of inflammatory cells is reported to play critical roles in the pathogenesis of hepatic IRI.
Enzhi Yin, Takeshi Fukuhara, Kazuyoshi Takeda, Yuko Kojima, Kyoko Fukuhara, Kenichi Ikejima, Hisashi Bashuda, Jiro Kitaura, Hideo Yagita, Ko Okumura, Koichiro Uchida   +10 more
doaj   +1 more source

Temporal Changes in Total Serum Immunoglobulin E Levels in East German Children and the Effect of Potential Predictors [PDF]

, 2011
Background: Elevated total serum immunoglobulin E (IgE) levels are a prominent feature of allergic and parasitic diseases. An epidemiologic study was conducted in East German children to describe trends in the development of total serum IgE levels and ...
Brüske, Irene, Flohrs, Katrin, Heinrich, Joachim, Rzehak, Peter, Thiering, Elisabeth, Wichmann, Heinz-Erich   +5 more
core   +1 more source